| IED ID | IndEnz0002005028 |
| Enzyme Type ID | protease005028 |
| Protein Name |
Integrin alpha-L CD11 antigen-like family member A Leukocyte adhesion glycoprotein LFA-1 alpha chain LFA-1A Leukocyte function-associated molecule 1 alpha chain Lymphocyte antigen 15 Ly-15 CD antigen CD11a |
| Gene Name | Itgal Lfa-1 Ly-15 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MSFRIAGPRLLLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGYQVLQIEDGVVVGAPGEGDNTGGLYHCRTSSEFCQPVSLHGSNHTSKYLGMTLATDAAKGSLLACDPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDGSQSLDRKDFEKILEFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNTFRAINYVVAHVFKEESGARPDATKVLVIITDGEASDKGNISAAHDITRYIIGIGKHFVSVQKQKTLHIFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEGTNRQDLTSFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLREDLQGATFVGQEPLTSDVRGGYLGYTVAWMTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGRWNQTQKIEGTQIGSYFGGELCSVDLDQDGEAELLLIGAPLFFGEQRGGRVFTYQRRQSLFEMVSELQGDPGYPLGRFGAAITALTDINGDRLTDVAVGAPLEEQGAVYIFNGKPGGLSPQPSQRIQGAQVFPGIRWFGRSIHGVKDLGGDRLADVVVGAEGRVVVLSSRPVVDVVTELSFSPEEIPVHEVECSYSAREEQKHGVKLKACFRIKPLTPQFQGRLLANLSYTLQLDGHRMRSRGLFPDGSHELSGNTSITPDKSCLDFHFHFPICIQDLISPINVSLNFSLLEEEGTPRDQKVGRAMQPILRPSIHTVTKEIPFEKNCGEDKKCEANLTLSSPARSGPLRLMSSASLAVEWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHSRMPVSCEELTEGSSLLTKTLKCNVSSPIFKAGQEVSLQVMFNTLLNSSWEDFVELNGTVHCENENSSLQEDNSAATHIPVLYPVNILTKEQENSTLYISFTPKGPKTQQVQHVYQVRIQPSAYDHNMPTLEALVGVPWPHSEDPITYTWSVQTDPLVTCHSEDLKRPSSEAEQPCLPGVQFRCPIVFRREILIQVTGTVELSKEIKASSTLSLCSSLSVSFNSSKHFHLYGSKASEAQVLVKVDLIHEKEMLHVYVLSGIGGLVLLFLIFLALYKVGFFKRNLKEKMEADGGVPNGSPPEDTDPLAVPGEETKDMGCLEPLRESDKD |
| Enzyme Length | 1162 |
| Uniprot Accession Number | P24063 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 466..474; /evidence=ECO:0000255; CA_BIND 528..536; /evidence=ECO:0000255; CA_BIND 588..596; /evidence=ECO:0000255 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (PubMed:2051027). Integrin ITGAL/ITGB2 is a receptor for F11R (By similarity). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:16234355, PubMed:24158516). Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis (PubMed:25108025). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. {ECO:0000250|UniProtKB:P20701, ECO:0000269|PubMed:16234355, ECO:0000269|PubMed:2051027, ECO:0000269|PubMed:24158516, ECO:0000269|PubMed:25108025, ECO:0000269|PubMed:29100055}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Calcium binding (3); Chain (1); Disulfide bond (8); Domain (1); Frameshift (1); Glycosylation (15); Motif (1); Repeat (7); Sequence conflict (7); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Calcium;Cell adhesion;Cell membrane;Direct protein sequencing;Disulfide bond;Glycoprotein;Integrin;Magnesium;Membrane;Metal-binding;Phagocytosis;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20701}; Single-pass type I membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | PTM: In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents. {ECO:0000250|UniProtKB:P20701}. |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000269|PubMed:3887182 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10201888; 10224287; 10227978; 10330002; 10503736; 10528208; 11069089; 11169416; 11390487; 11457896; 11756189; 11792712; 12391193; 12402981; 12471145; 12528895; 12543106; 12623845; 12652296; 12734371; 12756264; 12845325; 12847222; 1316530; 1346270; 1431091; 14530315; 14610273; 14634125; 14657281; 14688337; 14722085; 15064761; 15170225; 15210787; 15240673; 1526659; 15277234; 15284116; 15308480; 15322154; 15470040; 15585877; 15661900; 15677502; 15699108; 15726833; 15749873; 15749905; 15780986; 15955836; 16126897; 16239568; 16250049; 16374427; 16461431; 16585587; 16602821; 16636013; 1680807; 1686571; 16872848; 16996813; 17071583; 17116736; 17140403; 17207459; 17237371; 17641014; 17641028; 17646386; 17675580; 17702861; 17785425; 17851717; 17893676; 18239087; 18337659; 18354189; 18635688; 18644832; 18674934; 19008446; 19010554; 19064723; 19124737; 19223596; 19384874; 19428111; 19483086; 19608878; 19617540; 19946016; 20023213; 20069263; 20299514; 20435926; 20530790; 20569988; 20675589; 20805505; 20864093; 20884890; 20947763; 21108463; 21206905; 21244370; 21267068; 21460207; 21466654; 21659539; 2165966; 21907691; 21949652; 22447028; 22450813; 22711877; 22728064; 22763437; 22875786; 23310953; 23357382; 23380685; 23443048; 23585567; 23671277; 23708969; 23793062; 23817428; 24130503; 24436096; 24642468; 24670684; 25418718; 26214837; 26552706; 26612263; 26823454; 27286793; 27760339; 27977747; 28082358; 28087670; 28414311; 28755662; 2889817; 28954823; 28973166; 29150602; 29777221; 30012848; 30054208; 30131424; 30194420; 30258446; 30455459; 31085833; 31397024; 31636138; 31681316; 31772048; 32421906; 32553163; 32817592; 33193309; 33934334; 3710538; 3881766; 6193226; 6442265; 6785912; 6802749; 7161508; 7530713; 7608573; 7927501; 8043862; 8117278; 8482578; 8557754; 8562500; 8564091; 8666900; 8833147; 8903730; 8955185; 9314566; 9637488; 9713351; 9754575; 9878305; |
| Motif | MOTIF 1112..1116; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 128,314 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |