| IED ID | IndEnz0002005030 |
| Enzyme Type ID | protease005030 |
| Protein Name |
Integrin alpha-M CD11 antigen-like family member B CR-3 alpha chain Cell surface glycoprotein MAC-1 subunit alpha Leukocyte adhesion receptor MO1 Neutrophil adherence receptor CD antigen CD11b |
| Gene Name | ITGAM CD11B CR3A |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ |
| Enzyme Length | 1152 |
| Uniprot Accession Number | P11215 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 465..473; /evidence=ECO:0000255; CA_BIND 529..537; /evidence=ECO:0000255; CA_BIND 592..600; /evidence=ECO:0000255 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). {ECO:0000250|UniProtKB:P05555, ECO:0000269|PubMed:20008295, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:9558116, ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (6); Calcium binding (3); Chain (1); Disulfide bond (7); Domain (1); Glycosylation (19); Helix (14); Motif (1); Natural variant (4); Repeat (7); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (1) |
| Keywords | 3D-structure;Alternative splicing;Calcium;Cell adhesion;Cell membrane;Direct protein sequencing;Disulfide bond;Glycoprotein;Immunity;Innate immunity;Integrin;Magnesium;Membrane;Metal-binding;Receptor;Reference proteome;Repeat;Signal;Systemic lupus erythematosus;Transmembrane;Transmembrane helix |
| Interact With | O95870; Q13520; Q3SXY8; P11912; Q9HA82; P58418; Q96BA8; Q9UBT3; Q9GZR5; Q9Y282; P48165; P08034; Q5T7V8; O15529; Q7Z5P4; Q8N6L0; P48051; P43628; O14880; Q8N4V1; Q6IN84; P15941-11; O15173; P57054; P21246; Q9BRK0; Q9H6H4; Q96GQ5; Q9NY72; Q3KNW5; Q9NQQ7-3; Q8N9I0; Q9NUH8; Q8NBD8; Q4KMG9; Q9Y320 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000269|PubMed:3539202 |
| Structure 3D | NMR spectroscopy (2); X-ray crystallography (14) |
| Cross Reference PDB | 1BHO; 1BHQ; 1IDN; 1IDO; 1JLM; 1M1U; 1MF7; 1N9Z; 1NA5; 2LKE; 2LKJ; 3Q3G; 3QA3; 4M76; 4XW2; 6RHW; |
| Mapped Pubmed ID | 10201950; 11034990; 11881155; 11893077; 11937770; 11953106; 12009501; 12036876; 12107753; 12145463; 12165526; 12234260; 12244179; 12377763; 12377937; 12390020; 12393547; 12393719; 12444150; 12466503; 12485936; 12495676; 12516552; 12576754; 12600815; 12611591; 12665127; 12694184; 12760968; 12816955; 12847278; 12960243; 14532278; 14751053; 14769799; 15004192; 15073035; 15217824; 15277376; 15294914; 15304494; 15454120; 15485828; 15585684; 15615722; 15641787; 15718918; 15730520; 15741160; 15778383; 15976367; 16239529; 16249234; 16260637; 16357311; 16389569; 16508260; 16614246; 16751103; 16782049; 16915040; 17172930; 17202372; 17202407; 17228360; 17346796; 17372166; 17379836; 17445870; 17525755; 17721605; 17927697; 17957461; 18065787; 18096476; 18156711; 18164590; 18204098; 18375764; 18414903; 18495781; 18496641; 18509085; 18541300; 18617697; 18644795; 18676132; 18678668; 18684982; 18685529; 18714035; 18762778; 18842294; 18941116; 19052753; 19073595; 19086264; 19129174; 19135988; 19246218; 19250688; 19286673; 19387459; 19480860; 19546439; 19550115; 19572148; 19578722; 19587009; 19747912; 19748962; 19800635; 19811837; 19833726; 19863185; 19913121; 19939855; 20185670; 20228269; 20423844; 20483667; 20580686; 20628086; 20629846; 20665668; 20666624; 20706761; 20800911; 20824631; 20826754; 20848568; 20881011; 20962850; 21068098; 21135163; 21151989; 21252155; 21263017; 21273385; 21362770; 21403131; 21551251; 21571730; 21610569; 21676865; 21840425; 21874872; 22052909; 22053606; 22095715; 22229891; 22251373; 22552879; 22586164; 22722613; 22893614; 23092917; 23184931; 23257917; 23269830; 23334594; 23398146; 23451151; 23469114; 23479224; 23514737; 23573259; 23650620; 23671673; 23686079; 23708937; 23720274; 23727038; 23753600; 23754403; 23812215; 23880611; 23918739; 23981064; 24065820; 24264377; 24269694; 24373176; 24608226; 2462607; 24726062; 24782118; 24829201; 24945596; 25005557; 25024378; 25136078; 25231265; 25238263; 25305756; 25315704; 25365491; 25461401; 25554420; 25613106; 25655529; 25678086; 25826119; 25971554; 26036990; 26170143; 26293614; 26306739; 26309131; 26361072; 26411420; 26512111; 26763077; 26773105; 26852488; 27178742; 27339893; 27384580; 27460017; 27534550; 27606963; 28073885; 28183849; 28263189; 28292891; 28398520; 28669815; 28939773; 29049725; 29120575; 29207897; 29424023; 29575196; 29632532; 30041578; 30498196; 30619243; 30689427; 30712924; 30769810; 30967528; 31211819; 31227791; 31733719; 31774828; 31852826; 31907993; 32382571; 32693110; 32785810; 33148999; 33305306; 33539617; 34283878; 34588497; 3537192; 7529288; 7907877; 9723655; |
| Motif | MOTIF 1131..1135; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 127,179 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |