| IED ID | IndEnz0002005038 |
| Enzyme Type ID | protease005038 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 1b ADAM 1b EC 3.4.24.- Fertilin subunit alpha-b |
| Gene Name | Adam1b |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MERLKLGKIPEHWCIRLVAMLLLAIIFLPSTFCDIGSVYNSSYETVIPERLPGKGGKDPGGKVSYMLLMQGQKQLLHLEVKGHYPENNFPVYSYHNGILRQEMPLLSQDCHYEGYMEGVPGSFVSVNICSGLRGVLIKEETSYGIEPMLSSKNFEHVLYTMEHQPVVSCSVTPKDSPGDTSHPPRSRKPDDLLVLTDWWSHTKYVEMFVVVNHQRFQMWGSNINETVQAVMDIIALANSFTRGINTEVVLVGLEIWTEGDPIEVPVDLQTTLRNFNFWRQEKLVGRVRHDVAHLIVGHRPGENEGQAFLRGACSGEFAAAVEAFHHEDVLLFAALMAHELGHNLGIQHDHPTCTCGPKHFCLMGEKIGKDSGFSNCSSDHFLRFLHDHRGVCLLDEPGRQSRMRRAANCGNGVVEDLEQCDCGSDCDKSQCCDENCKLKGNSVCSTELCCFKCNFKKEGDVCRPADGPCDLEEYCNGTSAACPSDRKAQDGSKCHESFLCFNGQCMDPTFQCSRIFGHGSRSASDYCYTSLNSRGDQFGNCGSSSQFPKKYTKCSDKNVMCGKLICTEVAFLPQIQPNNLLLQVPETEDWCWSVAVFDMRDSLHEEYVKDNTYCGKDKVCKNSICEDFTPFSFPCSPSKQCNKHGVCNDLGNCHCSFGFAPPDCKEEGTGGSVDSGPAVNLSNDSSPGPNSTQSSTEELILNLKLIVLAVILVLMILLIIICIISAYTKSETASEAGPSELEELPEGEKEEQEEVLPEEAKGEEEELEYGKEEAEEQGAVEEEGAEEANEEAAAEKKDEDEEEGEE |
| Enzyme Length | 806 |
| Uniprot Accession Number | Q8R534 |
| Absorption | |
| Active Site | ACT_SITE 339; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: May play a role in spermatogenesis and sperm maturation. {ECO:0000303|PubMed:12095680}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (2); Disulfide bond (7); Domain (3); Glycosylation (6); Metal binding (3); Propeptide (1); Region (3); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..33; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12466851; 12711316; 15194697; 16141072; 16407235; 21267068; 7750654; 8786143; 9254906; 9675005; |
| Motif | |
| Gene Encoded By | |
| Mass | 89,369 |
| Kinetics | |
| Metal Binding | METAL 338; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 342; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 348; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.B8; |