| IED ID | IndEnz0002005042 |
| Enzyme Type ID | protease005042 |
| Protein Name |
Amyloid-beta A4 protein ABPP APP Alzheimer disease amyloid A4 protein homolog Amyloid precursor protein Amyloid-beta precursor protein Cleaved into: Amyloid-beta protein A-beta APP-beta |
| Gene Name | app |
| Organism | Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Euteleosteomorpha Neoteleostei Eurypterygia Ctenosquamata Acanthomorphata Euacanthomorphacea Percomorphaceae Eupercaria Tetraodontiformes (pufferfishes and others) Tetraodontoidei Tetradontoidea Tetraodontidae (puffers) Takifugu Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) |
| Enzyme Sequence | MGETTAFVLLLVATLTRSSEIPADDTVGLLTEPQVAMFCGKLNMHINVQNGKWESDPSGTKSCLNTKEGILQYCQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMNQCESHLHWHTVAKESCGDRSMNLHDYGMLLPCGIDRFRGVKFVCCPAETEQETDSSEVEGEESDVWWGGADPEYSENSPPTPSRATYVAGDAFERDENGDGDEDEEDDEDVDPTDEQESDERTANVAMTTTTTTTTESVEEVVRAVCWAQAESGPCRAMLERWYFNPKKRRCVPFLFGGCGGNRNNFESEEYCLAVCSSSLPTVAPSPPDAVDQYFEAPGDDNEHADFRKAKESLEAKHRERMSQVMREWEEAERQAKNLPRADKKAVIQHFQEKVEALEQEAAGERQQLVETHMARVEALLNSRRRLTLENYLGALQANPPRARQVLSLLKKYVRAEQKDRQHTLKHYEHVRTVDPKKAAQIRPQVLTHLRVIDERMNQSLALLYKVPSVASEIQNQIYPAAGSDCKDPVEHCVCPQVDGLVSYGNDALMPDQAYSSAPMDMGVDGLGSIDQSFNQANTENHVEPVDARPIPDRGLPTRPVSSLKLEEMPEVRTETDKRQSAGYEVYHQKLVFFADDVGSNKGAIIGLMVGGVVIATVIVITLVMLRKKQYTSIHHGVIEVDAAVTPEERHLARMQQNGYENPTYKFFEQMQN |
| Enzyme Length | 737 |
| Uniprot Accession Number | O93279 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (2); Compositional bias (3); Disulfide bond (9); Domain (3); Glycosylation (1); Metal binding (3); Motif (1); Region (4); Signal peptide (1); Site (2); Topological domain (2); Transmembrane (1) |
| Keywords | Amyloid;Copper;Disulfide bond;Glycoprotein;Membrane;Metal-binding;Protease inhibitor;Reference proteome;Serine protease inhibitor;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 724..729; /note=YENPXY motif; /evidence=ECO:0000250|UniProtKB:P05067 |
| Gene Encoded By | |
| Mass | 82,857 |
| Kinetics | |
| Metal Binding | METAL 148; /note=Copper; /evidence=ECO:0000255|PROSITE-ProRule:PRU01217; METAL 152; /note=Copper; /evidence=ECO:0000255|PROSITE-ProRule:PRU01217; METAL 169; /note=Copper; /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 |
| Rhea ID | |
| Cross Reference Brenda |