| IED ID | IndEnz0002005048 |
| Enzyme Type ID | protease005048 |
| Protein Name |
Pancreatic trypsin inhibitor Aprotinin Basic protease inhibitor BPI BPTI |
| Gene Name | |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MKMSRLCLSVALLVLLGTLAASTPGCDTSNQAKAQRPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGAIGPWENL |
| Enzyme Length | 100 |
| Uniprot Accession Number | P00974 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (6); Chain (1); Disulfide bond (3); Domain (1); Helix (2); Propeptide (2); Signal peptide (1); Site (1); Turn (1) |
| Keywords | 3D-structure;Direct protein sequencing;Disulfide bond;Pharmaceutical;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | P00760; Q52V24 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | NMR spectroscopy (10); X-ray crystallography (110) |
| Cross Reference PDB | 1AAL; 1B0C; 1BHC; 1BPI; 1BPT; 1BRB; 1BTH; 1BTI; 1BZ5; 1BZX; 1CBW; 1CO7; 1D0D; 1EAW; 1EJM; 1F5R; 1F7Z; 1FAK; 1FAN; 1FY8; 1G6X; 1JV8; 1JV9; 1K09; 1K6U; 1LD5; 1LD6; 1MTN; 1NAG; 1OA5; 1OA6; 1P2I; 1P2J; 1P2K; 1P2M; 1P2N; 1P2O; 1P2Q; 1PIT; 1QLQ; 1T7C; 1T8L; 1T8M; 1T8N; 1T8O; 1TPA; 1UUA; 1UUB; 1YKT; 1YLC; 1YLD; 2FI3; 2FI4; 2FI5; 2FTL; 2FTM; 2HEX; 2IJO; 2KAI; 2PTC; 2R9P; 2RA3; 2TGP; 2TPI; 2ZJX; 2ZVX; 3BTD; 3BTE; 3BTF; 3BTG; 3BTH; 3BTK; 3BTM; 3BTQ; 3BTT; 3BTW; 3FP6; 3FP7; 3FP8; 3GYM; 3LDI; 3LDJ; 3LDM; 3OTJ; 3P92; 3P95; 3TGI; 3TGJ; 3TGK; 3TPI; 3U1J; 3WNY; 4BNR; 4DG4; 4PTI; 4TPI; 4WWY; 4WXV; 4Y0Y; 4Y0Z; 4Y10; 4Y11; 5JB4; 5JB5; 5JB6; 5JB7; 5PTI; 5XX2; 5XX3; 5XX4; 5XX5; 5XX6; 5XX7; 5XX8; 5YVU; 5YW1; 6F1F; 6PTI; 7PTI; 8PTI; 9PTI; |
| Mapped Pubmed ID | 10089400; 10089443; 10210204; 10222201; 10653700; 10716178; 10731422; 10926503; 11320305; 11420435; 11696548; 11734212; 11841215; 12021452; 12206780; 12930996; 1384034; 14568540; 15299722; 15544809; 16120479; 1699222; 17157870; 17400917; 18054043; 18077447; 18692070; 18829434; 19388054; 19549826; 19830687; 20529698; 21245536; 21806544; 22031935; 22610453; 24034223; 2448484; 24859037; 24931377; 26175157; 28266637; 28870811; 29449928; 29910933; 31175706; 6188842; 6207021; 6210373; 7683059; 8518731; 9179777; 9214615; 9300481; 9760170; 9925787; |
| Motif | |
| Gene Encoded By | |
| Mass | 10,903 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |