| IED ID | IndEnz0002005110 |
| Enzyme Type ID | protease005110 |
| Protein Name |
Complement factor B EC 3.4.21.47 C3/C5 convertase Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment |
| Gene Name | Cfb Bf H2-Bf |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MESPQLCLVLLVLGFSSGGVSATPVLEARPQVSCSLEGVEIKGGSFQLLQGGQALEYLCPSGFYPYPVQTRTCRSTGSWSDLQTRDQKIVQKAECRAIRCPRPQDFENGEFWPRSPFYNLSDQISFQCYDGYVLRGSANRTCQENGRWDGQTAICDDGAGYCPNPGIPIGTRKVGSQYRLEDIVTYHCSRGLVLRGSQKRKCQEGGSWSGTEPSCQDSFMYDSPQEVAEAFLSSLTETIEGADAEDGHSPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGSSNFTGAKRCLTNLIEKVASYGVRPRYGLLTYATVPKVLVRVSDERSSDADWVTEKLNQISYEDHKLKSGTNTKRALQAVYSMMSWAGDAPPEGWNRTRHVIIIMTDGLHNMGGNPVTVIQDIRALLDIGRDPKNPREDYLDVYVFGVGPLVDSVNINALASKKDNEHHVFKVKDMEDLENVFYQMIDETKSLSLCGMVWEHKKGNDYHKQPWQAKISVTRPLKGHETCMGAVVSEYFVLTAAHCFMVDDQKHSIKVSVGGQRRDLEIEEVLFHPKYNINGKKAEGIPEFYDYDVALVKLKNKLKYGQTLRPICLPCTEGTTRALRLPQTATCKQHKEQLLPVKDVKALFVSEQGKSLTRKEVYIKNGDKKASCERDATKAQGYEKVKDASEVVTPRFLCTGGVDPYADPNTCKGDSGGPLIVHKRSRFIQVGVISWGVVDVCRDQRRQQLVPSYARDFHINLFQVLPWLKDKLKDEDLGFL |
| Enzyme Length | 761 |
| Uniprot Accession Number | P04186 |
| Absorption | |
| Active Site | ACT_SITE 523; /note=Charge relay system; ACT_SITE 573; /note=Charge relay system; ACT_SITE 696; /note=Charge relay system |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.; EC=3.4.21.47; |
| DNA Binding | |
| EC Number | 3.4.21.47 |
| Enzyme Function | FUNCTION: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (3); Disulfide bond (8); Domain (5); Glycosylation (4); Sequence conflict (2); Signal peptide (1) |
| Keywords | Cleavage on pair of basic residues;Complement alternate pathway;Disulfide bond;Glycoprotein;Hydrolase;Immunity;Innate immunity;Protease;Reference proteome;Repeat;Secreted;Serine protease;Signal;Sushi;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10229798; 10623824; 10686478; 11067947; 11283677; 11283678; 11359841; 11560991; 11804945; 11869678; 1203052; 12077276; 12091909; 12193734; 12196286; 12538716; 12794146; 12930357; 1351875; 1370685; 14660741; 14670299; 15048732; 15059809; 15102802; 15147568; 15322019; 15597324; 15879138; 15972690; 16002707; 16034123; 16141072; 16272350; 16304047; 16615889; 16615898; 16651386; 16670320; 16702544; 16842619; 16849499; 16849503; 17015743; 17024247; 17200182; 17237432; 17409188; 17420242; 17475881; 17523212; 17675237; 17916747; 18056835; 18160458; 18452991; 18501966; 18524992; 18541650; 18672286; 18684964; 18820683; 19112490; 19264882; 19273909; 19277984; 1970336; 19843088; 20004473; 20033053; 20065024; 20152175; 20413727; 20513133; 20660348; 20675597; 20709903; 20870940; 20952585; 20974996; 21257205; 21267068; 21502512; 21502587; 21642543; 21677750; 21943708; 22079428; 22156595; 22308431; 22457620; 22566568; 22689574; 22750071; 22819137; 22830570; 22918646; 23028050; 23337717; 23427256; 23825688; 24154627; 24167262; 24378428; 24474777; 24668752; 24740152; 24743949; 25593023; 25645888; 25725105; 2652811; 26787717; 27064393; 27295359; 27564415; 27626380; 28250926; 28301559; 28662037; 29137982; 29233958; 29279353; 29497373; 29531168; 30174588; 30301856; 3034587; 32369457; 33410734; 3353717; 33613523; 33740660; 34502486; 6088393; 6316336; 6550027; 6626149; 6816725; 6885117; 6919506; 6980940; 7641699; 7916002; 8624034; 8700167; 8706013; 8824158; 8939972; 9238044; 9244432; 9430715; 9507200; 9600320; |
| Motif | |
| Gene Encoded By | |
| Mass | 85,004 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.47; |