| IED ID | IndEnz0002005111 |
| Enzyme Type ID | protease005111 |
| Protein Name |
Aspartic protease 3 EC 3.4.23.- |
| Gene Name | asp-3 H22K11.1 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MSGRVFLLLALVALASAIQRIKLEKRTYTREQYKFGSIQEHLKAKYVPGYIPNKDAFNEGLSDYSNAQYYGPVTIGTPPQNFQVLFDTGSSNLWVPCANCPFGDIACRMHNRFDCKKSSSCTATGASFEIQYGTGSMKGTVDNDVVCFGHDTTYCTDKNQGLACATSEPGITFVAAKFDGIFGMGWDTISVNKISQPMDQIFANSAICKNQLFAFWLSRDANDITNGGEITLCDTDPNHYVGNIAWEPLVSEDYWRIKLASVVIDGTTYTSGPIDSIVDTGTSLLTGPTDVIKKIQHKIGGIPLFNGEYEVECSKIPSLPNITFNLGGQNFDLQGKDYILQMSNGNGGSTCLSGFMGMDIPAPAGPLWILGDVFIGRFYSVFDHGNKRVGFATSRTGK |
| Enzyme Length | 398 |
| Uniprot Accession Number | P55956 |
| Absorption | |
| Active Site | ACT_SITE 87; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 279; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Aspartic protease (Probable). Part of the necrosis cell death pathway (PubMed:12410314). Involved in neuronal cell degeneration (PubMed:12410314). Involved in heat stress response (PubMed:26795495). {ECO:0000269|PubMed:12410314, ECO:0000269|PubMed:26795495, ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (2); Domain (1); Glycosylation (1); Propeptide (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Cytoplasm;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Necrosis;Protease;Reference proteome;Secreted;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12410314}. Lysosome {ECO:0000269|PubMed:12410314}. Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11997343; 12845331; 14704431; 16636145; 17889653; 18927620; 20439774; 21177967; 21980510; 22286215; 22560298; 22810224; 23549480; 23800452; 25487147; 26009280; 26351692; 27506200; 30642431; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,399 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |