| IED ID | IndEnz0002005156 |
| Enzyme Type ID | protease005156 |
| Protein Name |
Capsid protein VP1 CP p59 Cleaved into: Soluble capsid protein Protein 30k p30 |
| Gene Name | ORF2 |
| Organism | Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US) |
| Taxonomic Lineage | Viruses Riboviria Orthornavirae Pisuviricota Pisoniviricetes Picornavirales Caliciviridae Norovirus Norwalk virus Norovirus isolates Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US) |
| Enzyme Sequence | MMMASKDATSSVDGASGAGQLVPEVNASDPLAMDPVAGSSTAVATAGQVNPIDPWIINNFVQAPQGEFTISPNNTPGDVLFDLSLGPHLNPFLLHLSQMYNGWVGNMRVRIMLAGNAFTAGKIIVSCIPPGFGSHNLTIAQATLFPHVIADVRTLDPIEVPLEDVRNVLFHNNDRNQQTMRLVCMLYTPLRTGGGTGDSFVVAGRVMTCPSPDFNFLFLVPPTVEQKTRPFTLPNLPLSSLSNSRAPLPISSMGISPDNVQSVQFQNGRCTLDGRLVGTTPVSLSHVAKIRGTSNGTVINLTELDGTPFHPFEGPAPIGFPDLGGCDWHINMTQFGHSSQTQYDVDTTPDTFVPHLGSIQANGIGSGNYVGVLSWISPPSHPSGSQVDLWKIPNYGSSITEATHLAPSVYPPGFGEVLVFFMSKMPGPGAYNLPCLLPQEYISHLASEQAPTVGEAALLHYVDPDTGRNLGEFKAYPDGFLTCVPNGASSGPQQLPINGVFVFVSWVSRFYQLKPVGTASSARGRLGLRR |
| Enzyme Length | 530 |
| Uniprot Accession Number | Q83884 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells. {ECO:0000269|PubMed:16840313}.; FUNCTION: Soluble capsid protein may play a role in viral immunoevasion. {ECO:0000269|PubMed:16840313}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (34); Chain (2); Helix (12); Region (6); Site (1); Turn (6) |
| Keywords | 3D-structure;Capsid protein;Host cytoplasm;Reference proteome;T=3 icosahedral capsid protein;Virion |
| Interact With | Itself |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Virion. Host cytoplasm. |
| Modified Residue | |
| Post Translational Modification | PTM: May be cleaved by host protease to generate soluble capsid protein. Assembled capsid cannot be cleaved. {ECO:0000269|PubMed:7853506}. |
| Signal Peptide | |
| Structure 3D | Electron microscopy (2); X-ray crystallography (14) |
| Cross Reference PDB | 1IHM; 2ZL5; 2ZL6; 2ZL7; 3BY1; 3BY2; 3D26; 5KW9; 5N7M; 6H6Y; 6H6Z; 6H70; 6H71; 6H72; 6OUT; 7KJP; |
| Mapped Pubmed ID | 18385236; 18599458; 27647885; 28505592; 30602609; 31182604; 33318483; |
| Motif | |
| Gene Encoded By | |
| Mass | 56,589 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |