| IED ID | IndEnz0002005158 |
| Enzyme Type ID | protease005158 |
| Protein Name |
Corticosteroid-binding globulin CBG Serpin A6 Transcortin |
| Gene Name | SERPINA6 CBG |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV |
| Enzyme Length | 405 |
| Uniprot Accession Number | P08185 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | BINDING 254; /note="Cortisol"; /evidence="ECO:0000269|PubMed:18513745, ECO:0007744|PDB:2VDY"; BINDING 286; /note="Cortisol"; /evidence="ECO:0000269|PubMed:18513745, ECO:0007744|PDB:2VDY"; BINDING 390; /note="Cortisol"; /evidence="ECO:0000269|PubMed:18513745, ECO:0007744|PDB:2VDY"; BINDING 393; /note="Cortisol" |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. {ECO:0000269|PubMed:18513745}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (18); Binding site (4); Chain (1); Glycosylation (6); Helix (12); Natural variant (3); Signal peptide (1); Site (1); Turn (5) |
| Keywords | 3D-structure;Direct protein sequencing;Disease variant;Glycoprotein;Lipid-binding;Reference proteome;Secreted;Signal;Steroid-binding;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated; binds 5 oligosaccharide chains.; PTM: Glycosylation in position Asn-260 is needed for steroid binding. |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000269|PubMed:3347061 |
| Structure 3D | X-ray crystallography (5) |
| Cross Reference PDB | 2VDX; 2VDY; 4BB2; 4C41; 4C49; |
| Mapped Pubmed ID | 11161981; 12154211; 12364459; 12554596; 14871264; 15554358; 15877287; 16222046; 17547679; 18617639; 18636124; 19011238; 19086053; 19172388; 19336370; 19723618; 19913121; 20226861; 20354921; 20379614; 20403506; 20628086; 20716560; 20839151; 21325280; 21750736; 21795453; 22072571; 22242800; 22337907; 22576823; 22932886; 23300763; 24246737; 24691024; 25010111; 25198130; 25251318; 25322275; 25335188; 25426859; 25636722; 26603673; 27300474; 27339896; 27887960; 29194043; 29273683; 29679879; 30160799; 30452386; 31103428; 33085168; 33469137; 7195404; |
| Motif | |
| Gene Encoded By | |
| Mass | 45,141 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |