| IED ID | IndEnz0002005201 |
| Enzyme Type ID | protease005201 |
| Protein Name |
DNA damage-inducible protein 1 EC 3.4.23.- |
| Gene Name | ddi1 AFUA_7G06050 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MTVELLKAIVESETSIPTNNQRLVYNNQLLGNDAQTLEQIGIGEGDMLGVHVTMRSPQAPARSIGGGPSAAAQQNLQRRQPMTPDPETIRLHILGDPRVREAVRRQNPELADAATDAQRFRDVLMAQQRREAQMEAEKEARIAMLNADPFNPENQREIEEIIRQNAVTENLHTAMEHHPESFGRVTMLYIPVEVNGHKVNAFVDSGAQVTIMSPECATACNIMRLVDRRYGGIAKGVGTATILGRVHSAQIKIGSMFLPCSFTVMEGKHIDLLLGLDMLKRHQACIDLKKGALVIQDEAVPFLGEADIPKELQEGFEDEPIVKGADGAEVGARTGAVTHQASGSGTSAAAPSSSTPRTNIRPAPSSRWPQDSIAKITELGFTREEAVRALDAANGDLDGAIGFLI |
| Enzyme Length | 405 |
| Uniprot Accession Number | Q4WGS4 |
| Absorption | |
| Active Site | ACT_SITE 204; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:P40087}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Domain (2); Region (2) |
| Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Protease;Protein transport;Reference proteome;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 43,897 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |