| IED ID | IndEnz0002005207 |
| Enzyme Type ID | protease005207 |
| Protein Name |
Desumoylating isopeptidase 1 homolog DeSI-1 EC 3.4.-.- Polyubiquitinated substrate transporter POST |
| Gene Name | F36D4.5 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MLTDLFYSTFGCLYSPTSTMDVMGTARRKTVVRLNVYDMYWLNDYASNIGVGIFHSGIEVFGVEYAYGGHPYQFSGVFENSPQDAEELGETFKFKESIVVGETERSTSDIRKLIKSLGEDFRGDRYHLISRNCNHFSAVLARELTGKDIPGWINRLANLSGSIPFLEKCIPQEWLTPIVLQASVDEKKRGSVDSAEEATEKLVVRSLNDSRTTILDNRTANGAIIMSASSSNSDRICMSPSSSSSASSCDTLDYDDLIVQTPSTFSSEKKSRSNSPPIFRIWNTIKATINGTQQTAPTGAATVIPASSASNIGKTNSTPGTTSNGLAKPTCSEC |
| Enzyme Length | 334 |
| Uniprot Accession Number | H2KZK4 |
| Absorption | |
| Active Site | ACT_SITE 55; /evidence=ECO:0000255|PROSITE-ProRule:PRU01205; ACT_SITE 133; /evidence=ECO:0000255|PROSITE-ProRule:PRU01205 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Protease which deconjugates SUMO from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubql-1 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). {ECO:0000250|UniProtKB:Q9CQT7, ECO:0000269|PubMed:29666234}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (1); Chain (1); Domain (1); Region (1) |
| Keywords | Alternative splicing;Cytoplasm;Hydrolase;Nucleus;Protease;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6ICB0}. Nucleus {ECO:0000250|UniProtKB:Q6ICB0}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15338614; 17164286; 17486083; 17850180; 19343510; 20439776; 21177967; 21367940; 22286215; 22347378; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 36,408 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |