| IED ID | IndEnz0002005218 |
| Enzyme Type ID | protease005218 |
| Protein Name |
Dipeptidyl peptidase 2 EC 3.4.14.2 Dipeptidyl aminopeptidase II Dipeptidyl peptidase 7 Dipeptidyl peptidase II DPP II Quiescent cell proline dipeptidase |
| Gene Name | Dpp7 Dpp2 Qpp |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MNFHPCYPVDHGVPSWILVLLLSLGLCNLQARADRVLDPDFHENYFEQYMDHFNFESFGNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSFANNSGFMVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRQDLGVHDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVVAVAGLGDSYQFFRDVTADFYGQSPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCQRLLNEGQRIMGLRALAGLVYNSSGTEPCYDIYRLYQSCADPTGCGTGSDARAWDYQACTEINLTFDSNNVTDMFPEIPFSEELRQQYCLDTWGVWPRQDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQSNLSTSVIAVTIQGGAHHLDLRASNSEDPPSVVEVRKLESTLIREWVAAARLKQPAMPRWPGPKKQHPSR |
| Enzyme Length | 506 |
| Uniprot Accession Number | Q9ET22 |
| Absorption | |
| Active Site | ACT_SITE 172; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 428; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 453; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.; EC=3.4.14.2; |
| DNA Binding | |
| EC Number | 3.4.14.2 |
| Enzyme Function | FUNCTION: Plays an important role in the degradation of some oligopeptides. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Glycosylation (6); Propeptide (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Aminopeptidase;Cytoplasmic vesicle;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..33; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11173530; 15703188; 16141072; 19819973; 21267068; 21469121; 21677750; 28728022; 29514215; |
| Motif | |
| Gene Encoded By | |
| Mass | 56,254 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |