| IED ID | IndEnz0002005232 |
| Enzyme Type ID | protease005232 |
| Protein Name |
FAS-associated death domain protein FAS-associating death domain-containing protein Mediator of receptor induced toxicity |
| Gene Name | Fadd Mort1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP |
| Enzyme Length | 205 |
| Uniprot Accession Number | Q61160 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. {ECO:0000250|UniProtKB:Q13158}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Domain (2); Helix (6); Modified residue (1); Region (1); Sequence conflict (1) |
| Keywords | 3D-structure;Apoptosis;Immunity;Innate immunity;Phosphoprotein;Reference proteome |
| Interact With | O89110; P25446; Q60855; Q9QZL0 |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 191; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:21183079 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | NMR spectroscopy (1) |
| Cross Reference PDB | 1FAD; |
| Mapped Pubmed ID | 10026132; 10072523; 10101687; 10403638; 10442092; 10463949; 10588860; 10862756; 10964568; 11034606; 11217851; 11353862; 11498534; 12063258; 12115619; 12466851; 12500197; 12705854; 12743602; 12817005; 12884866; 13679421; 14701813; 15017386; 15173180; 15337758; 15355863; 15376191; 15549108; 15632112; 15635090; 16009710; 16061179; 16116191; 16177127; 16183742; 16437623; 16469705; 16585540; 16688118; 16709845; 17030115; 17041756; 17159908; 17277150; 17292824; 17553783; 17785432; 18309324; 18445587; 18455983; 18543108; 18708583; 18946037; 19176810; 19194472; 19203997; 19301394; 19342627; 19524513; 19727529; 19855068; 20353946; 20487000; 20615958; 20889682; 20943999; 21052097; 21068410; 21115735; 21267068; 21368761; 21368763; 21382479; 21627969; 21677750; 21746883; 21804564; 21876153; 22000287; 22037414; 22089168; 22406316; 22582393; 22675671; 23144495; 23689606; 23727238; 23744592; 23828893; 23898178; 23935974; 24058479; 24144979; 24194600; 24375410; 24453255; 24548998; 24557836; 24799700; 24813850; 24832470; 24901053; 24971483; 25078620; 25132550; 25150572; 25278099; 25443631; 25500368; 25567679; 25581503; 25628462; 25641109; 25704009; 25767797; 25874713; 26104484; 26303234; 26437781; 26555174; 26649818; 26982364; 27007676; 27258329; 27286445; 27321907; 27357657; 27498868; 27523270; 27561390; 27584790; 27619661; 27626380; 27676214; 27767039; 27799292; 27819681; 27819682; 28273458; 28445730; 28574501; 28628031; 28919893; 29167229; 29203883; 29581256; 29695863; 29879109; 29891719; 30209212; 30250469; 30420664; 30692261; 30741936; 30988397; 31147458; 31239234; 31346084; 31493386; 31513427; 31519886; 31723262; 31869420; 32075762; 32428502; 33271062; 33278357; 33641090; 33976111; 34029184; 7536190; 9506948; 9521326; 9916988; |
| Motif | |
| Gene Encoded By | |
| Mass | 22,960 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |