| IED ID | IndEnz0002005237 |
| Enzyme Type ID | protease005237 |
| Protein Name |
Gag polyprotein Core polyprotein Pr72 Cleaved into: Matrix protein p19; Core protein p16; Capsid protein p35 Capsid protein p34 ; Probable nucleocapsid protein p10 |
| Gene Name | gag |
| Organism | Squirrel monkey retrovirus (SMRV-H) (SMRV-HLB) |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Betaretrovirus Squirrel monkey retrovirus (SMRV-H) (SMRV-HLB) |
| Enzyme Sequence | MGQASSHSENDLFISHLKESLKVRRIRVRKKDLVSFFSFIFKTCPWFPQEGSIDSRVWGRVGDCLNDYYRVFGPETIPITTFNYYNLIRDVLTNQSDSPDIQRLCKEGHKILISHSRPPSRQAPVTITTSEKASSRPPSRAPSTCPSVAIDIGSHDTGQSSLYPNLATLTDPPIQSPHSRAHTPPQHLPLLANSKTLHNSGSQDDQLNPADQADLEEAAAQYNNPDWPQLTNTPALPPFRPPSYVSTAVPPVAVAAPVLHAPTSGVPGSPTAPNLPGVALAKPSGPIDETVSLLDGVKTLVTKLSDLALLPPAGVMAFPVTRSQGQVSSNTTGRASPHPDTHTIPEEEEADSGESDSEDDEEESSEPTEPTYTHSYKRLNLKTIEKIKTAVANYGPTAPFTVALVESLSERWLTPSDWFFLSRAALSGGDNILWKSEYEDISKQFAERTRVRPPPKDGPLKIPGASPYQNNDKQAQFPPGLLTQIQSAGLKAWKRLPQKGAATTSLAKIRQGPDESYSDFVSRLQETADRLFGSGESESSFVKHLAYENANPACQSAIRPFRQKELSTMSPLLWYCSAHAVGLAIGAALQNLAPAQLLEPRPAFAIIVTNPAIFQETAPKKIQPPTQLPTQPNAPQASLIKNLGPTTKCPRCKKGFHWASECRSRLDINGQPIIKQGNLNRGQPQGPTTGMNSGASQFTPQYRQPTPALPVINHAATSQTSGEQQRAVQDWTSVPPPTQY |
| Enzyme Length | 740 |
| Uniprot Accession Number | P21411 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Matrix protein p10: Matrix protein. {ECO:0000305}.; FUNCTION: Nucleocapsid protein p14: Nucleocapsid protein. {ECO:0000305}.; FUNCTION: Capsid protein p27: capsid protein. {ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (5); Compositional bias (5); Initiator methionine (1); Lipidation (1); Motif (1); Region (4); Site (3) |
| Keywords | Capsid protein;Direct protein sequencing;Host-virus interaction;Lipoprotein;Myristate;Phosphoprotein;Repeat;Ribosomal frameshifting;Viral budding;Viral budding via the host ESCRT complexes;Viral matrix protein;Viral nucleoprotein;Viral release from host cell;Virion |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Capsid protein p35]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Matrix protein p19]: Virion {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | PTM: [Gag polyprotein]: Myristoylated. Myristoylation of the matrix (MA) domain mediates the transport and binding of Gag polyproteins to the host plasma membrane and is required for the assembly of viral particles. {ECO:0000250|UniProtKB:P10258}.; PTM: [Gag polyprotein]: Specific enzymatic cleavages in vivo yield mature proteins. {ECO:0000269|PubMed:448794, ECO:0000305|PubMed:3201749}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 396..399; /note=PTAP/PSAP motif; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 80,543 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |