| IED ID | IndEnz0002005238 |
| Enzyme Type ID | protease005238 |
| Protein Name |
Gag polyprotein Core polyprotein Cleaved into: Matrix protein p10; Phosphorylated protein pp24; Phosphorylated protein pp18; p12; Capsid protein p27; Nucleocapsid protein p14; p4 |
| Gene Name | gag |
| Organism | Simian retrovirus SRV-1 |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Betaretrovirus Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) Simian retrovirus SRV-1 |
| Enzyme Sequence | MGQELSQHERYVEQLKQALKTRGVKVKYADLLKFFDFVKDTCPWFPQEGTIDIKRWRRVGDCFQDYYNTFGPEKVPVTAFSYWNLIKELIDKKEVNPQVMAAVAQTEEILKTSSHTELTTKPSQNPDLDLISLDSDDEGAKGSSLKDKNLSCTKKPKRFPVLLTAQTSADPEDPNPSEVDWDGLEDEAAKYHNPDWPPFLTRPPPYNKATPSAPTVMAVVNPKEELKEKIAQLEEQIKLEELHQALISKLQKLKTGNETVTSPETAGGFSRTPHWPGQHIPKGKCCASREKEEQTPKDIFPVTETVDGQGQAWRHHNGFDFTVIKELKTAASQYGATAPYTLAIVESVADNWLTPTDWNTLVRAVLSGGDHLLWKSEFFENCRETAKRNQQAGNGWDFDMLTGSGNYSSTDAQMQYDPGLFAQIQAAATKAWRKLPVKGDPGASLTGVKQGPDEPFADFVHRLITTAGRIFGSAEAGVDYVKQLAYENANPACQAAIRPYRKKTDLTGYIRLCSDIGPSYQQGLAMAAAFSGQTVKDFLNNKNKEKGGCCFKCGRKGHFAKNCHEHIHNNSETKAPGLCPRCKRGKHWANECKSKTDSQGNPLPPHQGNGLRGQPQAPKQAYGAVSFVPANKNNPFQSLPEPPQEVQDWTSVPPPTQY |
| Enzyme Length | 658 |
| Uniprot Accession Number | P04022 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: [Matrix protein p10]: Matrix protein. {ECO:0000305}.; FUNCTION: [Nucleocapsid protein p14]: Nucleocapsid protein. {ECO:0000305}.; FUNCTION: [Capsid protein p27]: Capsid protein. {ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (8); Coiled coil (1); Compositional bias (3); Initiator methionine (1); Lipidation (1); Motif (2); Propeptide (1); Region (3); Site (6); Zinc finger (2) |
| Keywords | 3D-structure;Capsid protein;Cleavage on pair of basic residues;Coiled coil;Host-virus interaction;Lipoprotein;Metal-binding;Myristate;Phosphoprotein;Repeat;Ribosomal frameshifting;Viral budding;Viral budding via the host ESCRT complexes;Viral matrix protein;Viral nucleoprotein;Viral release from host cell;Virion;Zinc;Zinc-finger |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Matrix protein p10]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Capsid protein p27]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p14]: Virion {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | PTM: [Gag polyprotein]: Myristoylated. Myristoylation of the matrix (MA) domain mediates the transport and binding of Gag polyproteins to the host plasma membrane and is required for the assembly of viral particles. {ECO:0000250|UniProtKB:P10258}.; PTM: [Gag polyprotein]: Specific enzymatic cleavages in vivo yield mature proteins. {ECO:0000250|UniProtKB:P07567}. |
| Signal Peptide | |
| Structure 3D | NMR spectroscopy (2) |
| Cross Reference PDB | 2F76; 2F77; |
| Mapped Pubmed ID | 18647839; |
| Motif | MOTIF 203..206; /note=PPXY motif; /evidence=ECO:0000250|UniProtKB:P07567; MOTIF 211..214; /note=PTAP/PSAP motif; /evidence=ECO:0000250|UniProtKB:P07567 |
| Gene Encoded By | |
| Mass | 73,195 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |