| IED ID | IndEnz0002005360 |
| Enzyme Type ID | protease005360 |
| Protein Name |
Oxamate amidohydrolase proenzyme EC 3.5.1.126 Cleaved into: Oxamate amidohydrolase large chain Oxamate amidohydrolase alpha chain ; Oxamate amidohydrolase small chain Oxamate amidohydrolase beta chain |
| Gene Name | hpxW KPN_01768 |
| Organism | Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Klebsiella Klebsiella pneumoniae Klebsiella pneumoniae subsp. pneumoniae Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) |
| Enzyme Sequence | MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFWLIVPPEGDPIAIDASGAAGSLATLEAYAGQRHIPNRGPQAALTVAGTVSGWVEALRISRDLTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEELRHQPGFSETWLVAGEAPRPGSRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLTLQHQQGTLWNLAPPTQGLVSLAILGITDRLKMADADDAQTVHRIVEATKRAFALRDAHITDPRHLDVDVQQLLTPEALQPLADSIDDASASPWGGGKGPGDTVWMGVVDNSGLAVSFIQSIYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQPFHTLNPAAARLNDGRVMVYGSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIARLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY |
| Enzyme Length | 528 |
| Uniprot Accession Number | A6T9C8 |
| Absorption | |
| Active Site | ACT_SITE 342; /note=Nucleophile; /evidence=ECO:0000305|PubMed:27303801 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=H2O + oxamate = NH4(+) + oxalate; Xref=Rhea:RHEA:51512, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:30623, ChEBI:CHEBI:58363; EC=3.5.1.126; Evidence={ECO:0000269|PubMed:27303801}; |
| DNA Binding | |
| EC Number | 3.5.1.126 |
| Enzyme Function | FUNCTION: Involved in the uric acid degradation pathway. Catalyzes the conversion of oxamate to oxalate. {ECO:0000269|PubMed:27303801}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Beta strand (15); Chain (2); Helix (19); Mutagenesis (2); Region (1); Site (1); Turn (6) |
| Keywords | 3D-structure;Hydrolase;Protease;Reference proteome;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | PTM: Cleaved by autocatalysis into a large (alpha) and a small (beta) subunit. {ECO:0000269|PubMed:27303801}. |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 5HFT; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 55,542 |
| Kinetics | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: Note=kcat is 5.5 sec(-1) with oxamate as substrate. {ECO:0000269|PubMed:27303801}; |
| Metal Binding | |
| Rhea ID | RHEA:51512 |
| Cross Reference Brenda | 3.5.1.126; |