| IED ID | IndEnz0002005378 |
| Enzyme Type ID | protease005378 |
| Protein Name |
Chymotrypsin-C EC 3.4.21.2 Caldecrin |
| Gene Name | CTRC CLCR |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL |
| Enzyme Length | 268 |
| Uniprot Accession Number | Q99895 |
| Absorption | |
| Active Site | ACT_SITE 74; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 121; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 216; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.; EC=3.4.21.2; |
| DNA Binding | |
| EC Number | 3.4.21.2 |
| Enzyme Function | FUNCTION: Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. {ECO:0000269|PubMed:23430245}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (16); Chain (1); Disulfide bond (5); Domain (1); Glycosylation (3); Helix (5); Natural variant (38); Propeptide (1); Sequence conflict (2); Signal peptide (1); Turn (2) |
| Keywords | 3D-structure;Disease variant;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Serine protease;Signal;Zymogen |
| Interact With | A8MQ03; Q8TF65; O76011; Q07627; P60409; P60410; Q9BYR8; Q3LI66; Q9BYQ4; Q99750; Q8NI38; Q96LM6; A8MV65-2 |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 4H4F; |
| Mapped Pubmed ID | 17592142; 19096130; 19404200; 20625975; 21098023; 21323990; 21460362; 21631589; 22427236; 22539344; 2365696; 23951356; 25003218; 25383785; 25416956; 26013824; 26100556; 26166474; 27129265; 27409067; 27578509; 28095786; 28502372; 28968289; 29154238; 30277669; 31862184; 32014997; 32045777; 32948427; |
| Motif | |
| Gene Encoded By | |
| Mass | 29,484 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.2; |