| IED ID | IndEnz0002005436 |
| Enzyme Type ID | protease005436 |
| Protein Name |
Cystatin-S Cystatin-4 Cystatin-SA-III Salivary acidic protein 1 |
| Gene Name | CST4 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWEDRMSLVNSRCQEA |
| Enzyme Length | 141 |
| Uniprot Accession Number | P01036 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Modified residue (2); Motif (1); Natural variant (2); Sequence conflict (1); Signal peptide (1); Site (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Phosphoprotein;Protease inhibitor;Reference proteome;Secreted;Signal;Thiol protease inhibitor |
| Interact With | Q9UHD9 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20189825}. |
| Modified Residue | MOD_RES 21; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:1778989, ECO:0000269|PubMed:20189825"; MOD_RES 23; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:1741693, ECO:0000269|PubMed:1747107, ECO:0000269|PubMed:1778989, ECO:0000269|PubMed:20189825" |
| Post Translational Modification | PTM: Phosphorylated at both its N- and C-terminal regions. {ECO:0000269|PubMed:1741693, ECO:0000269|PubMed:1747107, ECO:0000269|PubMed:1778989, ECO:0000269|PubMed:1898055, ECO:0000269|PubMed:20189825}. |
| Signal Peptide | SIGNAL 1..20; /evidence="ECO:0000269|PubMed:1741693, ECO:0000269|PubMed:1747107, ECO:0000269|PubMed:1778989, ECO:0000269|PubMed:3496880" |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 24261636; 33811900; |
| Motif | MOTIF 76..80; /note=Secondary area of contact |
| Gene Encoded By | |
| Mass | 16,214 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |