| IED ID |
IndEnz0002005465 |
| Enzyme Type ID |
protease005465 |
| Protein Name |
DER1-like family member protein 1
|
| Gene Name |
DFM1 YDR411C D9461.2 |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Saccharomycotina (true yeasts)
Saccharomycetes
Saccharomycetales
Saccharomycetaceae
Saccharomyces
Saccharomyces cerevisiae (Baker's yeast)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
|
| Enzyme Sequence |
MAGPRNVRTLHGNGGRNNDVMGPKEFWLNIPPITRTLFTLAIVMTIVGRLNLINPWYFIYVWNLTFKKVQIWRLLTSCVMLSSRAMPALMELYSIYDRSSQLERGHFGPGLSNRRGPMVTVDYAYYLCFCILAITTATTIIYGSYYPVVLTSGFISCITYTWSIDNANVQIMFYGLIPVWGKYFPLIQLFISFVFNEGDFVISLIGFTTGYLYTCLDTHTLGPIWGMISRKADPTYGISPNGKFSTPWWFTSLYARITGAHNETATFNNNFANVPSSQRETRTFSGRGQRLGTAPATLSQTSGTDSGRASGSQLRSGPSNLNQFQGRGQRVGQTNSPSDSQ |
| Enzyme Length |
341 |
| Uniprot Accession Number |
Q12743 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear and its inability to complement der1 mutations, suggests either that it is not involved in degradation process of misfolded proteins, or that it participates in the destruction of specific misfolded ER luminal proteins. {ECO:0000269|PubMed:15093775}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Region (1); Topological domain (5); Transmembrane (4) |
| Keywords |
Endoplasmic reticulum;Membrane;Reference proteome;Stress response;Transmembrane;Transmembrane helix |
| Interact With |
P34223; P38349 |
| Induction |
INDUCTION: By endoplasmic reticulum stress. {ECO:0000269|PubMed:10847680}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15093775}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15093775}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
14690591;
15215855;
16179952;
16884526;
17083136;
18407841;
18719252;
19536198;
20579315;
21147851;
21266254;
23209158;
25231236;
25454947;
25666261;
|
| Motif |
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| Gene Encoded By |
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| Mass |
38,131 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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