| IED ID | IndEnz0002005516 |
| Enzyme Type ID | protease005516 |
| Protein Name |
Gut-specific cysteine proteinase EC 3.4.22.- |
| Gene Name | cpr-1 gcp-1 C52E4.1 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKFLILTALCAVTLAFVPINHQSAVETLTGQALVDYVNSAQSLFKTEHVEITEEEMKFKLMDGKYAAAHSDEIRATEQEVVLASVPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLLSCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHGAGCKPYPIAPCTSGNCPESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDFYKYKSGVYKHTAGKYLGGHAIKIIGWGTESGSPYWLVANSWGVNWGESGFFKIYRGDDQCGIESAVVAGKAKV |
| Enzyme Length | 329 |
| Uniprot Accession Number | P25807 |
| Absorption | |
| Active Site | ACT_SITE 113; /evidence=ECO:0000250; ACT_SITE 275; /evidence=ECO:0000250; ACT_SITE 295; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Thiol protease. Has a role as a digestive enzyme. {ECO:0000269|PubMed:1574082}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (6); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Hydrolase;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | INDUCTION: Activated by a GATA-like transcription factor. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12845331; 17889653; 21177967; 21209831; 21367940; 22560298; 23800452; 25487147; 29348603; 30773781; |
| Motif | |
| Gene Encoded By | |
| Mass | 35,397 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |