| IED ID | IndEnz0002005523 |
| Enzyme Type ID | protease005523 |
| Protein Name |
Clathrin interactor EPSIN 1 EPSIN-related 1 |
| Gene Name | EPSIN1 EPSINR1 At5g11710 T22P22.100 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MDFMKVFDQTVREIKREVNLKVLKVPEMEQKVLDATDNEPWGPHGTALAEIAQATKKFSECQMVMSVLWTRLSETGKDWRYVYKALAVIDYLISNGSERAVDEIIEHTYQISSLTSFEYVEPNGKDVGINVRKKAENIVALLNNKEKISEIRDKAVANRNKYVGLSSTGITYKSGSSASFGGSFQSGSSNFDSYKDRDSREDKNDYESFQKSRRGVKTEEQSYTSKKSFSRYGSTDHDNLSSGKKSPDSAKHRSYVSAAPSNNDDDFDDFDPRGTSSNKPSTGSANQVDLFGGDLIGDFLDSGPTETSSTNNNENFQEADLFADAAFVSASAQGAEFGSQTQKQVDLFSASEPSVTVSSAPPTVDLFASSESVVSPEAKISIPESMATPNIVDPFAAVPMDNFDGSDPFGAFTSHSASVSTGPQAPSVHGSATNTTSPLSFADSKPQHLQKKDPFQVKSGIWADSLSRGLIDLNITAPKKASLADVGVVGDLSNEDGNKASAASYYSGWSMGAGSGLGKTGLYSTQQQQQQQQQQQAPDISDDFFSSLSNQRYQSGGFKQ |
| Enzyme Length | 560 |
| Uniprot Accession Number | Q8VY07 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). Does not seem to bind to phospholipids. Plays an important role in the vacuolar trafficking of soluble cargo proteins at the trans-Golgi network. {ECO:0000250, ECO:0000269|PubMed:16905657}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (5); Domain (1); Erroneous gene model prediction (1); Motif (2); Region (3); Sequence conflict (1) |
| Keywords | Cytoplasm;Cytoplasmic vesicle;Cytoskeleton;Golgi apparatus;Protein transport;Reference proteome;Transport |
| Interact With | Q0WNJ6; Q84K16; P93026; Q9SEL6 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16905657}. Prevacuolar compartment {ECO:0000269|PubMed:16905657}. Cytoplasm {ECO:0000269|PubMed:16905657}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16905657}. Note=Associated with actin filaments. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11826309; 16615871; 17277094; 18775970; 20706207; 27247031; 30833711; 32094305; 32989160; |
| Motif | MOTIF 296..300; /note=Clathrin binding; /evidence=ECO:0000250; MOTIF 320..322; /note=ALPHA-ADR binding; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 60,634 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |