| IED ID | IndEnz0002005531 |
| Enzyme Type ID | protease005531 |
| Protein Name |
Enteropeptidase EC 3.4.21.9 Enterokinase Serine protease 7 Transmembrane protease serine 15 Cleaved into: Enteropeptidase non-catalytic mini chain; Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain |
| Gene Name | TMPRSS15 ENTK PRSS7 |
| Organism | Sus scrofa (Pig) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Suina Suidae (pigs) Sus Sus scrofa (Pig) |
| Enzyme Sequence | MGSKRIIPSRHRSLSTYEVMFTALFAILMVLCAGLIAVSWLTIKGSEKDAALGKSHEARGTMKITSGVTYNPNLQDKLSVDFKVLAFDIQQMIGEIFQSSNLKNEYKNSRVLQFENGSVIVIFDLLFAQWVSDENIKEELIQGIEANKSSQLVAFHIDVNSIDITESLENYSTTSPSTTSDKLTTSSPPATPGNVSIECLPGSRPCADALKCIAVDLFCDGELNCPDGSDEDSKICATACDGKFLLTESSGSFDAAQYPKLSEASVVCQWIIRVNQGLSIELNFSYFNTYSMDVLNIYEGVGSSKILRASLWLMNPGTIRIFSNQVTVTFLIESDENDYIGFNATYTAFNSTELNNDEKINCNFEDGFCFWIQDLNDDNEWERIQGTTFPPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLEPTLEPVCLSFWYYMYGENVYKLSINISNDQNIEKIIFQKEGNYGENWNYGQVTLNETVEFKVAFNAFKNQFLSDIALDDISLTYGICNVSLYPEPTLVPTSPPELPTDCGGPFELWEPNTTFTSMNFPNNYPNQAFCVWNLNAQKGKNIQLHFEEFDLENIADVVEIRDGEEDDSLLLAVYTGPGPVEDVFSTTNRMTVLFITNDALTKGGFKANFTTGYHLGIPEPCKEDNFQCENGECVLLVNLCDGFSHCKDGSDEAHCVRFLNGTANNSGLVQFRIQSIWHTACAENWTTQTSDDVCQLLGLGTGNSSMPFFSSGGGPFVKLNTAPNGSLILTASEQCFEDSLILLQCNHKSCGKKQVAQEVSPKIVGGNDSREGAWPWVVALYYNGQLLCGASLVSRDWLVSAAHCVYGRNLEPSKWKAILGLHMTSNLTSPQIVTRLIDEIVINPHYNRRRKDSDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRICSIAGWGKVIYQGSPADILQEADVPLLSNEKCQQQMPEYNITENMMCAGYEEGGIDSCQGDSGGPLMCLENNRWLLAGVTSFGYQCALPNRPGVYARVPKFTEWIQSFLH |
| Enzyme Length | 1034 |
| Uniprot Accession Number | P98074 |
| Absorption | |
| Active Site | ACT_SITE 840; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 891; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 986; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.; EC=3.4.21.9; |
| DNA Binding | |
| EC Number | 3.4.21.9 |
| Enzyme Function | FUNCTION: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (3); Disulfide bond (14); Domain (8); Glycosylation (22); Propeptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Repeat;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | PTM: The chains are derived from a single precursor that is cleaved by a trypsin-like protease.; PTM: The mini chain may be cleaved by elastase. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 18323639; |
| Motif | |
| Gene Encoded By | |
| Mass | 114,776 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.9; |