| IED ID | IndEnz0002005539 |
| Enzyme Type ID | protease005539 |
| Protein Name |
Fibrinolytic zinc metalloproteinase EC 3.4.24.- Fragment |
| Gene Name | |
| Organism | Ganoderma lucidum (Ling zhi medicinal fungus) (Bracket fungus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetes incertae sedis Polyporales Polyporaceae (bracket fungi) Ganoderma Ganoderma lucidum (Ling zhi medicinal fungus) (Bracket fungus) |
| Enzyme Sequence | QQRFPQRYVQLVITVDHVMN |
| Enzyme Length | 20 |
| Uniprot Accession Number | P86051 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Hydrolyzes alpha and beta chains of human fibrinogen and human fibrin. No activity against the gamma chain of human fibrinogen, human thrombin, bovine serum albumin, ovalbumin and hemoglobin. Has anticoagulant activity on human plasma and protects mice against death due from experimentally induced platelet thromboembolism with an ED(50) of 40 ug/kg. {ECO:0000269|Ref.1}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Non-terminal residue (1) |
| Keywords | Direct protein sequencing;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 2,472 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |