| IED ID | IndEnz0002005543 |
| Enzyme Type ID | protease005543 |
| Protein Name |
Furin-like protease 1, isoforms 1/1-X/2 Furin-1 EC 3.4.21.75 Kex2-like endoprotease 1 dKLIP-1 |
| Gene Name | Fur1 CG10772 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MKNDVVRWSRQPTSNTTNSSSSSRSDSNSTHKHRSKSNKLNARQLGSNAARSCQQRSSVATTLEDEQQTIIECDIGNFNFDCNLFKTSFLTQHKQKRSGKSSSKSKSNRSRPLAKTKAVFLLALQFSAVVFLCNINVGFVAGSVATAASSAGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPPPNKSSYVTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQQQQKNNKQDRNGVQTQRPKANSGEKSYDEKSRKVVGEITTNSGNGSIKAAKQVKESTTTSSNSRIPKLFERYEKIQAIFPELEPYENSSPKGKPKQAKQGKQFEVDLFKPTNGGNSRQGNTKKSPSVPPPSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAAGVMAPAQVEVEMEEVHATPDYEARKDQRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLGLSLLFFMIMQVFFLNFKHANDNNNKNKNNIIKCIR |
| Enzyme Length | 1269 |
| Uniprot Accession Number | P26016 |
| Absorption | |
| Active Site | ACT_SITE 372; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 413; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 587; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.; EC=3.4.21.75; |
| DNA Binding | |
| EC Number | 3.4.21.75 |
| Enzyme Function | FUNCTION: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (2); Chain (1); Compositional bias (8); Disulfide bond (3); Domain (2); Glycosylation (13); Propeptide (1); Region (6); Signal peptide (1); Transmembrane (2) |
| Keywords | Alternative splicing;Cleavage on pair of basic residues;Disulfide bond;Glycoprotein;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal;Transmembrane;Transmembrane helix;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:8491178}; Multi-pass membrane protein {ECO:0000269|PubMed:8491178}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..?; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10221902; 10436051; 10471706; 10993678; 11164041; 11381037; 11404335; 11536431; 11983148; 12204246; 12588842; 12642483; 12655012; 12879448; 15081360; 1545235; 16651547; 16989645; 17194782; 18690061; 18817735; 19433798; 19701455; 20074523; 20220848; 20371351; 20578951; 21074052; 21085633; 21480662; 22868267; 23063363; 23071443; 23087838; 23944235; 24412155; 24799692; 24896182; 25062361; 25165137; 25242144; 25294943; 25650358; 25687947; 25723514; 25970244; 26508274; 26512413; 26551273; 26954609; 27432119; 27496733; 28067623; 28627812; 28705811; 29848658; 30030826; 30592458; 30808704; 31012844; 32345615; 33563832; 33827210; 7836354; 7880443; 9070434; 9405303; 9692232; |
| Motif | |
| Gene Encoded By | |
| Mass | 138,627 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.75; |