| IED ID |
IndEnz0002005571 |
| Enzyme Type ID |
protease005571 |
| Protein Name |
14-3-3-like protein 2
|
| Gene Name |
ftt-2 F52D10.3 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MSDGKEELVNRAKLAEQAERYDDMAASMKKVTELGAELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGSEKKQQMAKEYREKVEKELRDICQDVLNLLDKFLIPKAGAAESKVFYLKMKGDYYRYLAEVASGDDRNSVVEKSQQSYQEAFDIAKDKMQPTHPIRLGLALNFSVFFYEILNAPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDAATDDTDANETEGGN |
| Enzyme Length |
248 |
| Uniprot Accession Number |
Q20655 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Required for extension of lifespan by sir-2.1 (PubMed:16777605). Required to modulate lifespan, in concert with hcf-1, acting redundantly with 14-3-3-like protein par-5 (PubMed:21909281). Promotes nuclear export of yap-1 (PubMed:23396260). Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm (PubMed:21531333). {ECO:0000269|PubMed:16777605, ECO:0000269|PubMed:21531333, ECO:0000269|PubMed:21909281, ECO:0000269|PubMed:23396260}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Mutagenesis (1); Site (1) |
| Keywords |
Cytoplasm;Nucleus;Reference proteome |
| Interact With |
G5EC23; Q11184; Q21921 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16777605, ECO:0000305|PubMed:21531333}. Nucleus {ECO:0000269|PubMed:16777605}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
11784094;
14704431;
16507136;
16672054;
16845399;
16860373;
17098225;
17417969;
17704769;
19123269;
19597959;
19922876;
20308279;
20620993;
21110867;
21177967;
22500807;
22560298;
23604319;
23800452;
25487147;
26009280;
26952210;
27129311;
27457958;
27506200;
28549065;
28648843;
29348603;
30353013;
31216475;
9171285;
|
| Motif |
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| Gene Encoded By |
|
| Mass |
28,067 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|