| IED ID | IndEnz0002005572 |
| Enzyme Type ID | protease005572 |
| Protein Name |
Taicatoxin, alpha-neurotoxin-like component TCX, alpha-neurotoxin-like component Fragment |
| Gene Name | |
| Organism | Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Elapidae Acanthophiinae Oxyuranus Oxyuranus scutellatus (Coastal taipan) Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan) |
| Enzyme Sequence | RRCFITPNVRSERCPPGQEVCFTKTXDG |
| Enzyme Length | 28 |
| Uniprot Accession Number | P0CJ35 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: The heterotrimer blocks the voltage-dependent L-type calcium channels (Cav1/CACNA1) from the heart, and the small conductance calcium-activated potassium channels (KCa2/KCNN) in the chromaffin cells and in the brain. Is very toxic to mice. {ECO:0000269|PubMed:15855042, ECO:0000269|PubMed:8901456, ECO:0000269|PubMed:9242659}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Non-terminal residue (1) |
| Keywords | Calcium channel impairing toxin;Calcium-activated potassium channel impairing toxin;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Potassium channel impairing toxin;Secreted;Toxin;Voltage-gated calcium channel impairing toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1485334}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 3,209 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |