| IED ID | IndEnz0002005677 |
| Enzyme Type ID | protease005677 |
| Protein Name |
Chymotrypsin-like elastase family member 3B EC 3.4.21.70 Elastase IIIB Elastase-3B Protease E Fragment |
| Gene Name | CELA3B ELA3B |
| Organism | Macaca mulatta (Rhesus macaque) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Cercopithecoidea Cercopithecidae (Old World monkeys) Cercopithecinae Macaca (macaques) Macaca mulatta (Rhesus macaque) |
| Enzyme Sequence | VASGYGPPSSHPSSRVVNGEDAVPYSWPWQVSLQYEKNGSFHHTCGGSLIAPDWVVTAGHCISSSLTYQVALGDYNLAVKEGPEQVIPINSGDLFVHPLWNRLCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQRALLPVVDYEHCSKWNWWGSTVKKTMVCAGGDIRSGCNGDSGGPLNCPTDDGGWQVHGVTSFVSSFGCNTQRKPTVFTRVSAFIDWIEETIASH |
| Enzyme Length | 257 |
| Uniprot Accession Number | O19023 |
| Absorption | |
| Active Site | ACT_SITE 60; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 110; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 204; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.; EC=3.4.21.70; |
| DNA Binding | |
| EC Number | 3.4.21.70 |
| Enzyme Function | FUNCTION: Efficient protease with alanine specificity but only little elastolytic activity. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (5); Domain (1); Glycosylation (1); Non-terminal residue (2); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL <1..2; /note=Or 3; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 27,687 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |