| IED ID | IndEnz0002005688 |
| Enzyme Type ID | protease005688 |
| Protein Name |
Antithrombin-III ATIII Serpin C1 |
| Gene Name | SERPINC1 AT3 |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MISNGIGTVTAGKRSICLLPLLLIGLWGCVTCHRSPVEDVCTAKPRDIPVNPMCIYRSSEKKATEGQGSEQKIPGATNRRVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLFGGKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAINEFTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVAESTQVLELPFKGDDITMVLILPKLEKTLAKVEQELTPDMLQEWLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRSLNSDRVTFKANRPILVLIREVALNTIIFMGRVANPCVD |
| Enzyme Length | 465 |
| Uniprot Accession Number | P41361 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | BINDING 82; /note=Heparin; /evidence=ECO:0000250; BINDING 162; /note=Heparin; /evidence=ECO:0000250; BINDING 178; /note=Heparin; /evidence=ECO:0000250 |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (14); Binding site (3); Chain (1); Disulfide bond (3); Glycosylation (4); Helix (11); Modified residue (2); Sequence conflict (4); Signal peptide (1); Site (1); Turn (8) |
| Keywords | 3D-structure;Blood coagulation;Direct protein sequencing;Disulfide bond;Glycoprotein;Hemostasis;Heparin-binding;Phosphoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}. |
| Modified Residue | MOD_RES 64; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P01008; MOD_RES 69; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01008 |
| Post Translational Modification | PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250|UniProtKB:P01008}. |
| Signal Peptide | SIGNAL 1..32; /evidence=ECO:0000269|PubMed:1930634 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1ATT; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 52,347 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |