| IED ID |
IndEnz0002005694 |
| Enzyme Type ID |
protease005694 |
| Protein Name |
Ghilanten
|
| Gene Name |
|
| Organism |
Haementeria ghilianii (Amazon leech) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Spiralia
Lophotrochozoa
Annelida
Clitellata
Hirudinea (leeches)
Rhynchobdellida
Glossiphoniidae
Haementeria
Haementeria ghilianii (Amazon leech)
|
| Enzyme Sequence |
QGPFGPGCEEAGCPEGSACNIITDRCTCPEVRCRVYCSHGFQRSRYGCEVCRCRTEPMKATCDISECPEGMMCSRLTNKCDCKIDINCRKTCPNGLKRDKLGCEYCECKPKRKLVPRLS |
| Enzyme Length |
119 |
| Uniprot Accession Number |
P16242 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: This highly disulfide-bonded protein is a potent inhibitor of factor Xa. May have therapeutic utility as an anticoagulant. Also exhibits a strong metastatic activity. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (10); Domain (2); Modified residue (1); Region (2); Site (2) |
| Keywords |
Direct protein sequencing;Disulfide bond;Heparin-binding;Protease inhibitor;Pyrrolidone carboxylic acid;Repeat;Secreted;Serine protease inhibitor |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:2306252 |
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
13,318 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|