| IED ID |
IndEnz0002005696 |
| Enzyme Type ID |
protease005696 |
| Protein Name |
Hirustasin
|
| Gene Name |
|
| Organism |
Hirudo medicinalis (Medicinal leech) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Spiralia
Lophotrochozoa
Annelida
Clitellata
Hirudinea (leeches)
Hirudinida
Hirudiniformes
Hirudinidae
Hirudo
Hirudo medicinalis (Medicinal leech)
|
| Enzyme Sequence |
TQGNTCGGETCSAAQVCLKGKCVCNEVHCRIRCKYGLKKDENGCEYPCSCAKASQ |
| Enzyme Length |
55 |
| Uniprot Accession Number |
P80302 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Acts as an inhibitor of tissue kallikrein, trypsin, chymotrypsin and neutrophil cathepsin G. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (6); Chain (1); Disulfide bond (5); Domain (1); Site (1) |
| Keywords |
3D-structure;Direct protein sequencing;Disulfide bond;Heparin-binding;Protease inhibitor;Secreted;Serine protease inhibitor |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (3) |
| Cross Reference PDB |
1BX7;
1BX8;
1HIA;
|
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
5,878 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|