| IED ID | IndEnz0002005703 |
| Enzyme Type ID | protease005703 |
| Protein Name |
Digestive cysteine proteinase 1 EC 3.4.22.- |
| Gene Name | LCP1 |
| Organism | Homarus americanus (American lobster) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Astacidea (true lobsters and crayfishes) Nephropoidea Nephropidae (clawed lobsters) Homarus Homarus americanus (American lobster) |
| Enzyme Sequence | MKVVALFLFGLALAAANPSWEEFKGKFGRKYVDLEEERYRLNVFLDNLQYIEEFNKKYERGEVTYNLAINQFSDMTNEKFNAVMKGYKKGPRPAAVFTSTDAAPESTEVDWRTKGAVTPVKDQGQCGSCWAFSTTGGIEGQHFLKTGRLVSLSEQQLVDCAGGSYYNQGCNGGWVERAIMYVRDNGGVDTESSYPYEARDNTCRFNSNTIGATCTGYVGIAQGSESALKTATRDIGPISVAIDASHRSFQSYYTGVYYEPSCSSSQLDHAVLAVGYGSEGGQDFWLVKNSWATSWGESGYIKMARNRNNNCGIATDACYPTV |
| Enzyme Length | 322 |
| Uniprot Accession Number | P13277 |
| Absorption | |
| Active Site | ACT_SITE 129; /evidence=ECO:0000250; ACT_SITE 269; /evidence=ECO:0000250; ACT_SITE 289; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by E-64, antipain, leupeptin, heavy metal ions, iodoacetic acid, dithionitrobenzene, p-hydroxymercuri-benzoate; activated by mercaptoethanol and dithiothreitol. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Propeptide (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 35,498 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |