| IED ID | IndEnz0002005715 |
| Enzyme Type ID | protease005715 |
| Protein Name |
Factor XIIa inhibitor XIIaINH |
| Gene Name | |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MASRLTPLTLLLLLLLAGDRVTSDMIVGPGNLQEGESEGDSQKGGILDGESIQGNEDSPTLPITNLTVVPATVTKPFSQPATEPVQSTIQPTAEPFCLAPVTSCSDSEIRSAEAVLGEALTDFSLRLYQDFSVLKKRETNFIFSPFSIASLLTQILLGAGGETRVSLEHLLSYPQNFSCVHHALRAFMSEGFTSFSQIFHSSDLTIKDTFAEASQRLYGSSPRPLGNDSTASLELINDWVAKKTNLRIRRLLDSLPEDTRLILLNAVALSAKWKIAFDKGRTSTKPFHLKSSAIKVPMMNSKKYPVASFTDRTLNRPGGRLQLSHNLSFVILVPQTVKHHLQDLEQALSTAVFKAVIKKLEMTKFHPTHLTMPRIKVQSSQDMLDYFDFIYDVNLCGLTEDPDVQVSGIRHQATLELTESGVDATAASVVSVARNLLLFEVQQPFLFLLWDQQHKFPVFMGRVYDPKG |
| Enzyme Length | 468 |
| Uniprot Accession Number | P50448 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Glycosylation (4); Region (1); Sequence conflict (12); Signal peptide (1); Site (1) |
| Keywords | Blood coagulation;Direct protein sequencing;Disulfide bond;Fibrinolysis;Glycoprotein;Hemostasis;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: N- and O-glycosylated. |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000269|PubMed:3814612 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 51,723 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |