| IED ID | IndEnz0002005724 |
| Enzyme Type ID | protease005724 |
| Protein Name |
Cathepsin B-like cysteine proteinase 4 EC 3.4.22.- Cysteine protease-related 4 |
| Gene Name | cpr-4 F44C4.3 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKYLILAALVAVTAGLVIPLVPKTQEAITEYVNSKQSLWKAEIPKDITIEQVKKRLMRTEFVAPHTPDVEVVKHDINEDTIPATFDARTQWPNCMSINNIRDQSDCGSCWAFAAAEAASDRFCIASNGAVNTLLSAEDVLSCCSNCGYGCEGGYPINAWKYLVKSGFCTGGSYEAQFGCKPYSLAPCGETVGNVTWPSCPDDGYDTPACVNKCTNKNYNVAYTADKHFGSTAYAVGKKVSQIQAEIIAHGPVEAAFTVYEDFYQYKTGVYVHTTGQELGGHAIRILGWGTDNGTPYWLVANSWNVNWGENGYFRIIRGTNECGIEHAVVGGVPKV |
| Enzyme Length | 335 |
| Uniprot Accession Number | P43508 |
| Absorption | |
| Active Site | ACT_SITE 109; /evidence=ECO:0000269|PubMed:28723894; ACT_SITE 281; /evidence=ECO:0000269|PubMed:28723894; ACT_SITE 301; /evidence=ECO:0000250|UniProtKB:P07858 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC. {ECO:0000269|PubMed:28723894}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (6); Glycosylation (1); Mutagenesis (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | INDUCTION: Induced by ultraviolet and ionizing radiation through a cep-1-dependent mechanism. {ECO:0000269|PubMed:28723894}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28723894}. Note=Secreted from animals irradiated with ultraviolet or ionizing gamma rays into the culture medium. {ECO:0000269|PubMed:28723894}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 14704431; 17164286; 19343510; 20439774; 21177967; 22286215; 22347378; 22560298; 23549480; 23800452; 25487147; 25635455; 29348603; 30642431; |
| Motif | |
| Gene Encoded By | |
| Mass | 36,493 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.1; |