| IED ID | IndEnz0002005729 |
| Enzyme Type ID | protease005729 |
| Protein Name |
DNA damage-inducible protein 1 EC 3.4.23.- |
| Gene Name | DDI1 DEHA2F25058g |
| Organism | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Debaryomyces Debaryomyces hansenii (Yeast) (Torulaspora hansenii) Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
| Enzyme Sequence | MRLTISNESNNQILSVDISESMTLEDFQAYIQAEFDISPQDQSLKHNGKPLSGSDKSLEDLGLNNDDLVLLGKTSVGSTTASSGSSVTANSNNSNAVDFQIEAMRTQFLSNPQLNSQLRQSNPQLHSTLNNPSEFKNSVIGSLQQFQNGATPGSYNPQQQEQLSRLQDNPDDPESQSRILEMIRQERIDENMQLAYEIAPESFTSVNMLYINIKVNGVLVQAFVDSGAQSTIISPKLADKCGISRLIDRRFVGEARGVGSQKIEGKIHSVPIAIGDSDTHIPCSFIVIDTHVDLLFGLDMLRRHKCVLDLERDVLVVGGNIETKFLHESEIQANPFLPGVAGSSASAGGTGGTFGGQGIALGSNSAENNNVTSSIVPANSTPDTTKQKAPNAAANAAVKRQDTGNSSSKFSESDIKQLVSLGFSKQEAIFALEQSQGNVEVAASLLFQ |
| Enzyme Length | 448 |
| Uniprot Accession Number | Q6BK42 |
| Absorption | |
| Active Site | ACT_SITE 225; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:P40087}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Domain (2); Region (2) |
| Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Protease;Protein transport;Reference proteome;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 48,132 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |