| IED ID |
IndEnz0002005734 |
| Enzyme Type ID |
protease005734 |
| Protein Name |
Iron-uptake system-binding protein
|
| Gene Name |
feuA BSU01630 |
| Organism |
Bacillus subtilis (strain 168) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Terrabacteria group
Firmicutes
Bacilli
Bacillales
Bacillaceae
Bacillus
Bacillus subtilis group
Bacillus subtilis
Bacillus subtilis subsp. subtilis
Bacillus subtilis (strain 168)
|
| Enzyme Sequence |
MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYLDKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGEKMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLTGKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYGDLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWKSLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN |
| Enzyme Length |
317 |
| Uniprot Accession Number |
P40409 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: Involved in the uptake of iron. {ECO:0000269|PubMed:16672620}.; FUNCTION: Part of the ABC transporter complex FeuABC/YusV involved in import of the catecholate siderophores bacillibactin and enterobactin. {ECO:0000305|PubMed:16672620}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (13); Chain (1); Domain (1); Helix (16); Lipidation (2); Signal peptide (1); Turn (2) |
| Keywords |
3D-structure;Cell membrane;Cytoplasm;Ion transport;Iron;Iron transport;Lipoprotein;Membrane;Palmitate;Reference proteome;Signal;Transport |
| Interact With |
|
| Induction |
INDUCTION: Repressed by fur. Induced by Btr in iron-limited conditions. {ECO:0000269|PubMed:16672620, ECO:0000269|PubMed:17725565}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20713508, ECO:0000269|PubMed:22882210, ECO:0000305|PubMed:16672620}; Lipid-anchor {ECO:0000305|PubMed:16672620}. Cytoplasm {ECO:0000269|PubMed:16672620}. Membrane raft {ECO:0000269|PubMed:20713508, ECO:0000269|PubMed:22882210}; Lipid-anchor {ECO:0000305|PubMed:16672620}. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion. {ECO:0000269|PubMed:20713508, ECO:0000269|PubMed:22882210}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
SIGNAL 1..19; /evidence=ECO:0000255|PROSITE-ProRule:PRU00303 |
| Structure 3D |
X-ray crystallography (5) |
| Cross Reference PDB |
2PHZ;
2WHY;
2WI8;
2XUZ;
2XV1;
|
| Mapped Pubmed ID |
19746494;
21802011;
|
| Motif |
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| Gene Encoded By |
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| Mass |
35,108 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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