| IED ID |
IndEnz0002005738 |
| Enzyme Type ID |
protease005738 |
| Protein Name |
Transcriptional regulatory protein GAT1
|
| Gene Name |
GAT1 CAALFM_C405880WA CaO19.1275 CaO19.8862 |
| Organism |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Saccharomycotina (true yeasts)
Saccharomycetes
Saccharomycetales
Debaryomycetaceae
Candida/Lodderomyces clade
Candida
Candida albicans (Yeast)
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
|
| Enzyme Sequence |
MYYRARHSLPYQKRMENLTWRMMYINNKSIFTNTNNAPKEIFEQSLDPEIDDFDYVAHIKKIGQFNQQKTQQQQDHLQSNLDNHNSIFADNTGFSNNNDRGSSGGGMTSISSLSKKRPAPFSPMIQPEKTTIIPTATNTMSQLSQQLNEFNKFNHPSQTSNFNDVNHHMEISTSHIAPTSSAFEFSLDPLAFEGPNQNFQPEPHHDFNTNSFDSMTSSYERPLFDDFLPRDHHNIQSSSVPTSASSFSTIVPKNTQFSTSASITSPTSTFSNQGNNSSNFHRLNSTVSITATPGNLLRQESMVSLPDYANHLRSMSQTPTMNSSNAPFSHSFNDGGSYFMNNFTGITLPSQPSPQPIHFDNKPKDDHFNTSLSVSQQQPSAKKSKRKSTITKSKKKAASPETTITSTGSTITTKSTNSNSTGKGTATGPAASNTGVSCTNCGTKTTPLWRRNPQGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRQRGNNNGSGNSSGTTNNSNNYNNKSISKKNEIDDGDDLNPTSITNNTGLTNNNNSKSPAKSKKKSNFDNNSNSALNNLDKSKLKINTNEITNISETTSNSSSPVINLNHGGRSSGVFGNTPDYLNGITSPAVSLVKSEIDNPHQLNNSNSNGMLMTMHQSSHQSSLSTTFDHEVESNNEGSNSSGVNTSTANNQDWDWLNMNY |
| Enzyme Length |
688 |
| Uniprot Accession Number |
Q5A432 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model. {ECO:0000269|PubMed:14617156, ECO:0000269|PubMed:17369441, ECO:0000269|PubMed:17950010, ECO:0000269|PubMed:18547391, ECO:0000269|PubMed:20884691, ECO:0000269|PubMed:22194462}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (6); Region (5); Zinc finger (1) |
| Keywords |
Metal-binding;Nucleus;Reference proteome;Transcription;Transcription regulation;Virulence;Zinc;Zinc-finger |
| Interact With |
|
| Induction |
INDUCTION: Expression is induced by rapamycine. {ECO:0000269|PubMed:19197361}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
75,488 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|