| IED ID | IndEnz0002005787 |
| Enzyme Type ID | protease005787 |
| Protein Name |
Hepatocyte growth factor-like protein Macrophage stimulatory protein Macrophage-stimulating protein MSP Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain |
| Gene Name | MST1 D3F15S2 DNF15S2 HGFL |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRCGPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRLG |
| Enzyme Length | 711 |
| Uniprot Accession Number | P26927 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (16); Chain (3); Disulfide bond (20); Domain (6); Glycosylation (3); Helix (4); Natural variant (4); Sequence conflict (6); Signal peptide (1); Turn (2) |
| Keywords | 3D-structure;Direct protein sequencing;Disulfide bond;Glycoprotein;Kringle;Reference proteome;Repeat;Secreted;Serine protease homolog;Signal |
| Interact With | Q04912; Q8WV19; Q15831 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains. |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 2ASU; 4QT8; |
| Mapped Pubmed ID | 12177064; 12919677; 14597639; 15632155; 15764806; 15792801; 16170349; 17347649; 17456594; 17554261; 17554300; 18438406; 18480548; 18587394; 18700007; 1885621; 19456860; 19657358; 19760754; 19861958; 19915572; 19944697; 20014019; 20024904; 20307617; 20545605; 20726546; 21072187; 21081472; 21249150; 21619683; 21723047; 21931648; 22245154; 22554193; 23011677; 23422030; 23928732; 24136289; 24409221; 25193665; 25315688; 25551685; 25704570; 27609031; 29441677; 30212651; 30795621; 30981108; 31254927; 32156191; 32692720; 33070035; 33109096; 8346233; 9657372; |
| Motif | |
| Gene Encoded By | |
| Mass | 80,320 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |