| IED ID | IndEnz0002005814 |
| Enzyme Type ID | protease005814 |
| Protein Name |
Gag polyprotein Pr71Gag Cleaved into: Gag protein p68 ; p3 |
| Gene Name | gag |
| Organism | Simian foamy virus type 3 (strain LK3) (SFVagm) (SFV-3) |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Spumaretrovirinae Spumavirus African green monkey simian foamy virus Simian foamy virus 3 Simian foamy virus type 3 (strain LK3) (SFVagm) (SFV-3) |
| Enzyme Sequence | MGDHNLNVQELLNLFQNLGIPRQPNHREVIGLRMLGGWWGPGTRYILVSIFLQDDSGQPLQQPRWRPEGRPVNPLVHNTIEAPWGELRQAFEDLDVAEGTLRFGPLANGNWIPGDEYSMEFQPPLAQEIAQMQRDELEEILDITGQICAQVIDLVDMQDAQIRGLERRIQDRLGLRDNLPVAGIQAPPSSPIGQPIASSSLQPIPGSSSSPADLDGIWTPRQIDPRLSRVAYNPFLPGSSDGSGGSIPVQPSAPPAVLPSLPSLPAPVSQPIIQYVAQPPVPAPQAIPIQHIRAVTGNTPTNPRDIPMWLGRHSAAIEGVFPMTTPDLRCRVVNALIGGSLGLSLEPIHCVNWAAVVAALYVRTHGSYPIHELANVLRAVVTQEGVATGFQLGIMLSNQDYNLVWGILRPLLPGQAVVTAMQQRLDQEVNDAARITSFNGHLNDIYQLLGLNARGQSIARAQSASTSGNSASAGRGRRGQRTQQQAGRQQQQQTRRTNQGNQGQRDNNQRQSSGGNQGQRGQGGYDLRPRTYQPQRYGGGRGRRWNDNQQQQQAQPGRSSDQPRSQSQQPQPEARGDQSRTSGAGRGQQGRGNQNRNQRRADANNTRNVDTVTATTTSSSTASSGQNGSSTTPPASGSRNQGD |
| Enzyme Length | 643 |
| Uniprot Accession Number | P27400 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (3); Compositional bias (3); Erroneous initiation (1); Motif (2); Region (7); Site (4) |
| Keywords | Capsid protein;Cytoplasmic inwards viral transport;DNA-binding;Host cytoplasm;Host nucleus;Host-virus interaction;Microtubular inwards viral transport;RNA-binding;Viral budding;Viral budding via the host ESCRT complexes;Viral nucleoprotein;Viral release from host cell;Virion;Virus entry into host cell |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Gag protein]: Virion {ECO:0000250}. Host nucleus {ECO:0000250}. Host cytoplasm {ECO:0000250}. Note=Gag protein is nuclear at initial phase, cytoplasmic at assembly. Shortly after infection, Gag protein is targeted to centrosomes. It is then actively transported into the nucleus thanks to its nuclear localization signal. In the late phases of infection, Gag proteins assemble in the cytoplasm to form the virion's capsids (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [p3]: Virion {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Specific enzymatic cleavages in vivo by viral protease yield mature proteins. The protease is not cleaved off from Pol. Since cleavage efficiency is not optimal for all sites, intermediary molecules are expressed (By similarity). {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 251..254; /note=PTAP/PSAP motif; MOTIF 523..544; /note=Nuclear localization signal; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 69,786 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |