| IED ID | IndEnz0002005815 |
| Enzyme Type ID | protease005815 |
| Protein Name |
Gag polyprotein Pr71Gag Cleaved into: Gag protein p68Gag ; p3 p3Gag |
| Gene Name | gag |
| Organism | Simian foamy virus (isolate chimpanzee) (SFVcpz) |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Spumaretrovirinae Spumavirus Simian foamy virus Simian foamy virus (isolate chimpanzee) (SFVcpz) |
| Enzyme Sequence | MASGSNVEEYELDVEALVVILRDRNIGRNPLHGEIIGLRLTEGWWGQLERFQMVRLILQDEDNEPLQRPRHEIIPRAVNPHTMFVLSGPLAELQLAFQDLDLPEGPLRFGPLANGHYVEGDPYSRSYRPVTMAETAQMTRDELEDTLNTQSEIEIQMINLLELYEVETRALRRQLAERSSIGQGGISPGASHSRPPVSSFSGLPSLPAIPGIHTRAPSPPRATSTPGNIPRSLGDDNMPSSSFAGPSQPRVSFHPGNPFAEAEGHRPRSQSRERRRDIPSAPVISAPVPSAPPMIQYIPVPPPPPVGAVIPIQHIRSVTGEPPRNPREIPIWLGRNAPAIDGVFPTTTPDLRCRIINALLGGNLGLSLTPGDCITWDSAVATLFIRTYGQYPLHQLGNVLKGIADQEGVATAYTLGMMLSGQNYQLVSGIIRGYLPGQAVVTAMQQRLDQEIDDQTRAETFIQHLNAVYEILGLNARGQSIRASVTPQPRPSRGRGRGQSAPEPSQGPVNSGRGRQCPAPGQNDRGSNIQNQGQENSSQGGYNLRSRTYQPQRYGGGRGRRWNENTNNSETRPTEQSPQTPRPIQAGSGVRGNQSQTYKPAAGRGGRGNQNRNQRSSGAGDSRAVNTVTQSATSSTDESSSTTTAAPSGGQGN |
| Enzyme Length | 653 |
| Uniprot Accession Number | Q87039 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (3); Compositional bias (6); Motif (2); Region (6); Site (4) |
| Keywords | Capsid protein;Cytoplasmic inwards viral transport;DNA-binding;Host cytoplasm;Host nucleus;Host-virus interaction;Microtubular inwards viral transport;RNA-binding;Reference proteome;Viral budding;Viral budding via the host ESCRT complexes;Viral nucleoprotein;Viral release from host cell;Virion;Virus entry into host cell |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Gag protein]: Virion. Host nucleus. Host cytoplasm. Note=Nuclear at initial phase, cytoplasmic at assembly. Shortly after infection, Gag protein is targeted to centrosomes. It is then actively transported into the nucleus thanks to its nuclear localization signal. In the late phases of infection, Gag proteins assemble in the cytoplasm to form the virion's capsids (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [p3]: Virion {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Specific enzymatic cleavages in vivo by viral protease yield mature proteins. The protease is not cleaved off from Pol. Since cleavage efficiency is not optimal for all sites, intermediary molecules are expressed (By similarity). {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 25292281; |
| Motif | MOTIF 289..292; /note=PTAP/PSAP motif; MOTIF 540..561; /note=Nuclear localization signal; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 70,762 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |