| IED ID | IndEnz0002005819 |
| Enzyme Type ID | protease005819 |
| Protein Name |
Secreted aspartic protease FUS4 EC 3.4.23.- Fusarin biosynthesis protein 4 |
| Gene Name | FUS4 FVEG_11083 |
| Organism | Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Nectriaceae Fusarium Fusarium fujikuroi species complex Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium verticillioides) Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) |
| Enzyme Sequence | MLTIATLHVALQVFGAFSPSHAAAVTLEHRSARDGNSVAVPANWDVYGYLFNVTVGSPPQNITMLSDMTWMAPFVRSGRCLGQFNPELCVAQGQSFFNEHNSTTFANTTFAQATWPVTAFAPNFTVDYGRDKFCIGEICNKDTLMQVSDFPYPGSVVPVIPFGGIFGLAPTPEAITATSEPVNFQAWKNGKMGPLVGWHTCEVLKSAATCQGGDAQLVFGGTDTTMYSAKKLQSYEIQNPEWLSDAFYPSTPPRSNYWSTSLTGMWIRTDKLSKNYAVPFKAVKTAKRTPPLAVVDEGSEGLGAPLSLNGYKYLVRHIKSAKLASKAIVQNIQQQGSSGYNTADQDWYTVACDGLHEYPDLVYQLDGRKKYTISAGDYVTKLTDMPGSVCYLNINVWKYGRTENGDARVVLLGRAFLKRKYLVLNFEDRSFGLAPLRTG |
| Enzyme Length | 439 |
| Uniprot Accession Number | W7MX26 |
| Absorption | |
| Active Site | ACT_SITE 67; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103; ACT_SITE 296; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Secreted aspartic protease; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:22652150). Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (By similarity). The other FUS cluster members are not essential for fusarin C biosynthesis (By similarity). {ECO:0000250|UniProtKB:S0ELJ9, ECO:0000269|PubMed:22652150}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (1); Domain (1); Glycosylation (5); Signal peptide (1) |
| Keywords | Aspartyl protease;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:D4ATH2}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 48,222 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |