| IED ID | IndEnz0002005845 |
| Enzyme Type ID | protease005845 |
| Protein Name |
Mast cell carboxypeptidase A EC 3.4.17.1 Carboxypeptidase A3 R-CPA RMC-CP Fragment |
| Gene Name | Cpa3 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | LMGVIYSTLAIAPVQFDREKVFRVKLQDEKQASILKNLTQTIELDFWYPDAIHDIAVNMTVDFRVTEKESQTIQSTLEQHKMDYEILINDLQEEIDKQFDVKEEIAGRHSYAKYNDWNKIVSWTEKMVEKHPEMVSRIKIGSTVEDNPLYVLKIGRKDGERKAIFMDCGIHAREWVSPAFCQWFVYQAAKSYGKNKIMTKLLDRMNFYVLPVFNVDGYIWSWTKDRMWRKNRSKNPNSTCIGTDLNRNFDVSWDSSPNTDNPCLSVYRGPAPESEKETKAVTNFIRSHLNSIKAYITFHSYSQMLLFPYGYTIKLPPNHQDLLKVARIATDVLSSRYETRYIYGPIASTIYKTSGSSLDWAYDLGIKHTFAFELRDKGKSGFLLPESRIKPTCKETMLSVKFIAKYILKHTS |
| Enzyme Length | 412 |
| Uniprot Accession Number | P21961 |
| Absorption | |
| Active Site | ACT_SITE 373; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P00730 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.; EC=3.4.17.1; |
| DNA Binding | |
| EC Number | 3.4.17.1 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (2); Metal binding (3); Non-terminal residue (1); Propeptide (1); Sequence conflict (2); Signal peptide (1) |
| Keywords | Carboxypeptidase;Cytoplasmic vesicle;Direct protein sequencing;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL <1..10; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 24953986; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,944 |
| Kinetics | |
| Metal Binding | METAL 171; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 174; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 299; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730 |
| Rhea ID | |
| Cross Reference Brenda |