| IED ID | IndEnz0002005855 |
| Enzyme Type ID | protease005855 |
| Protein Name |
Pro-cathepsin H Cysteine protease Cleaved into: Cathepsin H mini chain; Cathepsin H EC 3.4.22.16 ; Cathepsin H heavy chain; Cathepsin H light chain |
| Gene Name | CP MTR_4g125300 MtrunA17_Chr0c27g0493921 MtrunA17_Chr4g0070441 |
| Organism | Medicago truncatula (Barrel medic) (Medicago tribuloides) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids fabids Fabales Fabaceae Papilionoideae 50 kb inversion clade NPAAA clade Hologalegina IRL clade Trifolieae Medicago (medics) Medicago truncatula (Barrel medic) (Medicago tribuloides) |
| Enzyme Sequence | MAQWTLLIVFFCVATAAAGLSFHDSNPIRMVSDMEEQLLQVIGESRHAVSFARFANRYGKRYDTVDEMKRRFKIFSENLQLIKSTNKKRLGYTLGVNHFADWTWEEFRSHRLGAAQNCSATLKGNHRITDVVLPAEKDWRKEGIVSEVKDQGHCGSCWTFSTTGALESAYAQAFGKNISLSEQQLVDCAGAYNNFGCNGGLPSQAFEYIKYNGGLETEEAYPYTGQNGLCKFTSENVAVQVLGSVNITLGAEDELKHAVAFARPVSVAFQVVDDFRLYKKGVYTSTTCGSTPMDVNHAVLAVGYGIEDGVPYWLIKNSWGGEWGDHGYFKMEMGKNMCGVATCSSYPVVA |
| Enzyme Length | 350 |
| Uniprot Accession Number | A0A072UTP9 |
| Absorption | |
| Active Site | ACT_SITE 157; /evidence=ECO:0000255|PROSITE-ProRule:PRU10088; ACT_SITE 297; /evidence=ECO:0000255|PROSITE-ProRule:PRU10089; ACT_SITE 317; /evidence=ECO:0000255|PROSITE-ProRule:PRU10090 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.; EC=3.4.22.16; Evidence={ECO:0000305}; |
| DNA Binding | |
| EC Number | 3.4.22.16 |
| Enzyme Function | FUNCTION: May play a role in proteolysis leading to mobilization of nitrogen during senescence and starvation. {ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (3); Disulfide bond (3); Erroneous gene model prediction (1); Glycosylation (3); Peptide (1); Propeptide (2); Sequence conflict (3); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Vacuole;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole {ECO:0000250|UniProtKB:Q8H166}. Lysosome {ECO:0000250|UniProtKB:P07688}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 38,752 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |