| IED ID | IndEnz0002005867 |
| Enzyme Type ID | protease005867 |
| Protein Name |
Cathepsin C EC 3.4.22.- |
| Gene Name | |
| Organism | Schistosoma mansoni (Blood fluke) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Platyhelminthes Trematoda Digenea (flukes) Strigeidida Schistosomatoidea Schistosomatidae (blood flukes) Schistosoma Schistosoma mansoni (Blood fluke) |
| Enzyme Sequence | MHWVFHCILIILACLRFTCADTPANCTYEDAHGRWKFHIGDYQSKCPEKLNSKQSVVISLLYPDIAIDEFGNRGHWTLIYNQGFEVTINHRKWLVIFAYKSNGEFNCHKSMPMWTHDTLIDSGSVCSGKIGVHDKFHINKLFGSKSFGRTLYHINPSFVGKINAHQKSWRGEIYPELSKYTIDELRNRAGGVKSMVTRPSVLNRKTPSKELISLTGNLPLEFDWTSPPDGSRSPVTPIRNQGICGSCYASPSAAALEARIRLVSNFSEQPILSPQTVVDCSPYSEGCNGGFPFLIAGKYGEDFGLPQKIVIPYTGEDTGKCTVSKNCTRYYTTDYSYIGGYYGATNEKLMQLELISNGPFPVGFEVYEDFQFYKEGIYHHTTVQTDHYNFNPFELTNHAVLLVGYGVDKLSGEPYWKVKNSWGVEWGEQGYFRILRGTDECGVESLGVRFDPVL |
| Enzyme Length | 454 |
| Uniprot Accession Number | Q26563 |
| Absorption | |
| Active Site | ACT_SITE 247; /evidence=ECO:0000255|PROSITE-ProRule:PRU10089; ACT_SITE 398; /evidence=ECO:0000255|PROSITE-ProRule:PRU10089; ACT_SITE 420; /evidence=ECO:0000255|PROSITE-ProRule:PRU10089 |
| Activity Regulation | |
| Binding Site | BINDING 291; /note=Chloride; /evidence=ECO:0000250; BINDING 337; /note=Chloride; /evidence=ECO:0000250 |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Thiol protease. Has a role as a digestive enzyme. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Binding site (2); Chain (1); Disulfide bond (3); Glycosylation (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Lysosome. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 51,281 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |