| IED ID | IndEnz0002005902 |
| Enzyme Type ID | protease005902 |
| Protein Name |
Cathepsin L EC 3.4.22.15 SMCL1 |
| Gene Name | CL1 |
| Organism | Schistosoma mansoni (Blood fluke) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Platyhelminthes Trematoda Digenea (flukes) Strigeidida Schistosomatoidea Schistosomatidae (blood flukes) Schistosoma Schistosoma mansoni (Blood fluke) |
| Enzyme Sequence | MPVNLEYLGFKLPGNVDEKYVQFKLKYRKQYHETEDEIRFNIFKSNILKAQLYQVFVRGSAIYGVTPYSDLTTDEFARTHLTASWVVPSSRSNTPTSLGKEVNNIPKNFDWREKGAVTEVKNQGMCGSCWAFSTTGNVESQWFRKTGKLLSLSEQQLVDCDGLDDGCNGGLPSNAYESIIKMGGLMLEDNYPYDAKNEKCHLKTDGVAVYINSSVNLTQDETELAAWLYHNSTISVGMNALLLQFYQHGISHPWWIFCSKYLLDHAVLLVGYGVSEKNEPFWIVKNSWGVEWGENGYFRMYRGDGSCGINTVATSAMIY |
| Enzyme Length | 319 |
| Uniprot Accession Number | Q26534 |
| Absorption | |
| Active Site | ACT_SITE 129; /evidence=ECO:0000250; ACT_SITE 265; /evidence=ECO:0000250; ACT_SITE 286; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.; EC=3.4.22.15; |
| DNA Binding | |
| EC Number | 3.4.22.15 |
| Enzyme Function | FUNCTION: May be crucial for metabolism of host hemoglobin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Glycosylation (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Lysosome. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..?; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 36,136 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.B49; |