| IED ID | IndEnz0002005906 |
| Enzyme Type ID | protease005906 |
| Protein Name |
Caspase-12 CASP-12 EC 3.4.22.- |
| Gene Name | |
| Organism | Canis lupus familiaris (Dog) (Canis familiaris) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Carnivora Caniformia Canidae (dog coyote wolf fox) Canis Canis lupus (Gray wolf) Canis lupus familiaris (Dog) (Canis familiaris) |
| Enzyme Sequence | MAGKRQSQDPVNAIKVVASTMLNSFLEDLKEKNVLNKQELQTMGQTVNVITKKTENLVGDLTEKTQVVGKIFKDHFLNSGSLLSLKSHAENEDECSESSSAVLQEIQASQVKVRKLCPCDHSHEPKITNVHEIYPVMEKEGRTRLALIICNSEFDYLSKRQGSEIDILGMQDLLENLGYSVVVKENLSALEMKTELKNFAARQEHKFSDSTFLVFMSHGTLDGICGTKHRNEEPDILHDDTIFQIFNNRNCRSLKDKPKVIIMQACRGRGDGAVWVTDVGEASAWTCDQPLQCYIFNDAIEKTHVEKDFIAFKSSTPHNVSWRLNTDGSLFISHLIHYFREFSCCHHLEEIFRKVQNSFETPNTMIQMPTIERVSMTRYFYLFPGN |
| Enzyme Length | 386 |
| Uniprot Accession Number | Q075B4 |
| Absorption | |
| Active Site | ACT_SITE 218; /evidence=ECO:0000250; ACT_SITE 266; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (1); Chain (1); Domain (1); Modified residue (1); Propeptide (1) |
| Keywords | Alternative splicing;Apoptosis;Hydrolase;Phosphoprotein;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 84; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q920D5 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 44,020 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |