| IED ID | IndEnz0002005914 |
| Enzyme Type ID | protease005914 |
| Protein Name |
Caspase-12 CASP-12 EC 3.4.22.- |
| Gene Name | |
| Organism | Macaca mulatta (Rhesus macaque) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Cercopithecoidea Cercopithecidae (Old World monkeys) Cercopithecinae Macaca (macaques) Macaca mulatta (Rhesus macaque) |
| Enzyme Sequence | MADKKPSKEDPVNMVKLLTRNVLDGIFDDLMENNVLNTEELRNLGKGLNFMVNNAGNLVDNITEKAQMVGKILKDRLLSHPKQLSLEYQHESEDQESEESSASSSSSTESEEENEESKDEERAASAHSMAVPPTAPLEIQGAQPSGRLKLCPHAHFRELKTKRADEIYPVMEKEGRTRLALIICSKEFHYLLNRNGSELDLLGMQDLLENLGYSVVIEENLTAQEMETALRQFAARPEHQSSDSTFLVFMSHGILNGICGTKHWDQEPDVLHDDTIFEIFNNRNCRSLRDKPKVIIMQACRGSGAGIVWFTTDSGKASADTHGQLLQSSICNDAVTKAHVEKDFIAFKSSTPHNVSWRHEMSGSVFISQIIYYFKEYSWSHHLEEIFRKVQRSFETPNVVTQLPTIERLSMTRYFYLFPGN |
| Enzyme Length | 421 |
| Uniprot Accession Number | Q153Z0 |
| Absorption | |
| Active Site | ACT_SITE 252; /evidence=ECO:0000250; ACT_SITE 300; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Modified residue (1); Propeptide (1); Region (1) |
| Keywords | Apoptosis;Hydrolase;Phosphoprotein;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 85; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q920D5 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 47,759 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |