| IED ID | IndEnz0002005920 |
| Enzyme Type ID | protease005920 |
| Protein Name |
Calpain EC 3.4.22.- Calcium-activated neutral proteinase CANP |
| Gene Name | |
| Organism | Schistosoma mansoni (Blood fluke) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Platyhelminthes Trematoda Digenea (flukes) Strigeidida Schistosomatoidea Schistosomatidae (blood flukes) Schistosoma Schistosoma mansoni (Blood fluke) |
| Enzyme Sequence | MGRIQIVYSPDENVSGRTNRPGKEVVDPRTGRIIKVKRETPDDYLNVLKPIKGPKRMEFNPYLPKTLTPKGYAKFKLMMNVASKQYETLVKRLKTERTLWEDPDFPANDKAIGNLPDFRERIEWKRPHEINPNAKFFAGGASRFDIEQGALGDCWLLAVVASISGYPQLFDQVVPKDQELKGPEYVGVVRFRFWRFGHWVEVLIDDRLPVRQGRNTLVFMHSNDPTEFWSALLEKAYAKLNGCYAHLSGGSQSEAMEDLTGGICLSLELNQKERPSDLIDQLKIYAQRCCLMGCSIDSSVMEQKMDNGLIGSHAYSLTGVYPVNYRGRTQWLMRLRNPWGDSHEWKGAWCDGSPQWREISEQEKKNINLSFTADGEFWMSYEDFVTCFSRVEVCHLGLESLEYNQNFHGKRRLDEAIFSGQWQRNVNAGGCINNRTTYWTSPQFRITVEDPDPDDDDNKCSVLIGLMQTDIRKKVGADFQPIGFMVYNAPDDLNTLLSRAQLLTRSPIAKSQFINTREVTAQFRVPPGSYVVIPSTFDPNIEVNFILRVFSQTSITEQELDEDNTNQGLPDDVIEALKLEDTLLDEDQEIEQKFLAIRDPKTNAINAVKLGELLNNSTLQDIPNFQGFNKELCRSMVASVDNNLTGHVELNEFMDLWIQAKGWKHIFIKHDVDQSGYFSAYEFREALNDAGYHVSNRLINAIINRYQDPGTDKISFEDFMLCMVRLKTAFETIEAHPKNIEGTSLFSAEDYLRFSVYI |
| Enzyme Length | 758 |
| Uniprot Accession Number | P27730 |
| Absorption | |
| Active Site | ACT_SITE 154; /evidence=ECO:0000250; ACT_SITE 313; /evidence=ECO:0000250; ACT_SITE 337; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Activated by free cytoplasmic calcium. |
| Binding Site | |
| Calcium Binding | CA_BIND 641..652; /note=1; /evidence=ECO:0000305; CA_BIND 671..682; /note=2; /evidence=ECO:0000305 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Calpains are calcium-activated non-lysosomal thiol-proteases. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Calcium binding (2); Chain (1); Domain (3); Region (3); Sequence conflict (6) |
| Keywords | Calcium;Hydrolase;Metal-binding;Protease;Reference proteome;Repeat;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 86,863 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |