| IED ID | IndEnz0002005932 |
| Enzyme Type ID | protease005932 |
| Protein Name |
Endoplasmic reticulum metallopeptidase 1 EC 3.4.-.- Felix-ina |
| Gene Name | ERMP1 FXNA KIAA1815 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MEWGSESAAVRRHRVGVERREGAAAAPPPEREARAQEPLVDGCSGGGRTRKRSPGGSGGASRGAGTGLSEVRAALGLALYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLLEQIKLIEVQSNSLHKISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDGAQHAVLANCHFDSVANSPGASDDAVSCSVMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAASKYRHGNMVFFDVLGLFVIAYPSRIGSIINYMVVMGVVLYLGKKFLQPKHKTGNYKKDFLCGLGITLISWFTSLVTVLIIAVFISLIGQSLSWYNHFYVSVCLYGTATVAKIILIHTLAKRFYYMNASAQYLGEVFFDISLFVHCCFLVTLTYQGLCSAFISAVWVAFPLLTKLCVHKDFKQHGAQGKFIAFYLLGMFIPYLYALYLIWAVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFIYLAKSTKKTMLTLTLVCAITFLLVCSGTFFPYSSNPANPKPKRVFLQHMTRTFHDLEGNAVKRDSGIWINGFDYTGISHITPHIPEINDSIRAHCEENAPLCGFPWYLPVHFLIRKNWYLPAPEVSPRNPPHFRLISKEQTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSLGNGTPVTSKGGDYFVFYSHGLQASAWQFWIEVQVSEEHPEGMVTVAIAAHYLSGEDKRSPQLDALKEKFPDWTFPSAWVCTYDLFVF |
| Enzyme Length | 904 |
| Uniprot Accession Number | Q7Z2K6 |
| Absorption | |
| Active Site | ACT_SITE 251; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. {ECO:0000250|UniProtKB:Q6UPR8}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (2); Chain (1); Compositional bias (1); Disulfide bond (1); Erroneous initiation (1); Glycosylation (2); Metal binding (6); Modified residue (1); Natural variant (1); Region (1); Sequence conflict (2); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Acetylation;Alternative splicing;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | P41181; Q13520; Q9UN42; Q9BXK5; J3KQ12; Q8TD46-4; O00501; O95471; O95484; Q9UHP7-3; Q96BA8; P60508; Q5JX71; Q8TBE3; P48165; O15529; Q9NZD1; Q9UM44; P31937; Q9Y5U9; P38484; Q9UGI6-2; P26715; Q6UWN5; Q95460-2; Q9BQ51; O00623; Q9UBD6; Q9UKG4; A1A5C7-2; Q8TBB6; Q9NPE6; Q8WWF3; Q96Q45-2; Q9NWC5; Q96HE8 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6UPR8}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | MOD_RES 1; /note=N-acetylmethionine; /evidence=ECO:0007744|PubMed:22223895 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17267443; 26496610; 27566589; 29523216; |
| Motif | |
| Gene Encoded By | |
| Mass | 100,231 |
| Kinetics | |
| Metal Binding | METAL 205; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 217; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 217; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 252; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 278; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 354; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |