| IED ID | IndEnz0002005971 |
| Enzyme Type ID | protease005971 |
| Protein Name |
Carboxypeptidase E CPE EC 3.4.17.10 Carboxypeptidase H CPH Enkephalin convertase Prohormone-processing carboxypeptidase |
| Gene Name | cpe |
| Organism | Lophius americanus (American angler) (Anglerfish) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Euteleosteomorpha Neoteleostei Eurypterygia Ctenosquamata Acanthomorphata Euacanthomorphacea Percomorphaceae Eupercaria Lophiiformes (anglerfishes) Lophioidei Lophiidae (goosefishes) Lophius Lophius americanus (American angler) (Anglerfish) |
| Enzyme Sequence | MKQICSIVLLGAAVVSLVSAAGSDSEISFEYHRYEELRKALVSVWLQCPTIARIYTIGESFEGRELLVLEMSDNPGTHEPGEPEFKYIANMHGNEAVGRELLIYLAQYLCNQYQQGNETIIDLIHSTRIHLMPSMNPDGFEKAASQPGEIKDWFVGRSNAQGVDLNRNFPDLDRIIYTNEREGGANNHLLQNMKKAVDENTKLAPETKAVIHWIMEIPFVLSANLHGGDVVANYPYDETRTGSTHEYSASPDDVIFKSLAKAFSIYNPVMSDPQRPPCRKHDDDSSFKDGITNGGAWYSVPGGMQDFNYLSSNCFEITLELSCDKFPNEDTLKTYWEQNRNSLVNYIEQVHRGVKGYVRDLQGNPIFNATISVEGIDHDITTAKDGDYWRLLRQGNYKVAASAPGYLTVIKKVAVPHSPATRVDFELESLMERKEEEREELMDWWKMMSETLNF |
| Enzyme Length | 454 |
| Uniprot Accession Number | P37892 |
| Absorption | |
| Active Site | ACT_SITE 320; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:P14384 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of C-terminal arginine or lysine residues from polypeptides.; EC=3.4.17.10; |
| DNA Binding | |
| EC Number | 3.4.17.10 |
| Enzyme Function | FUNCTION: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (2); Metal binding (3); Signal peptide (1) |
| Keywords | Carboxypeptidase;Cytoplasmic vesicle;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P15087}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15087}. Secreted {ECO:0000250|UniProtKB:P15087}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250|UniProtKB:P15087}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 51,416 |
| Kinetics | |
| Metal Binding | METAL 92; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 95; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730; METAL 226; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P00730 |
| Rhea ID | |
| Cross Reference Brenda |