| IED ID | IndEnz0002005974 |
| Enzyme Type ID | protease005974 |
| Protein Name |
Pro-cathepsin H Cleaved into: Cathepsin H mini chain; Cathepsin H EC 3.4.22.16 ; Cathepsin H heavy chain; Cathepsin H light chain |
| Gene Name | CTSH CPSB |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV |
| Enzyme Length | 335 |
| Uniprot Accession Number | P09668 |
| Absorption | |
| Active Site | ACT_SITE 141; /evidence=ECO:0000250; ACT_SITE 281; /evidence=ECO:0000250; ACT_SITE 301; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.; EC=3.4.22.16; |
| DNA Binding | |
| EC Number | 3.4.22.16 |
| Enzyme Function | FUNCTION: Important for the overall degradation of proteins in lysosomes. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (12); Chain (3); Disulfide bond (4); Glycosylation (2); Helix (14); Natural variant (5); Peptide (1); Propeptide (2); Sequence conflict (2); Signal peptide (1); Turn (2) |
| Keywords | 3D-structure;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | Q86V38; Q14204; Q92876 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Lysosome. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 6CZK; 6CZS; |
| Mapped Pubmed ID | 10072072; 10580105; 10631941; 10748235; 10809954; 11684289; 11813165; 11853874; 12078484; 12742663; 12748383; 1568474; 16181339; 17601350; 18977241; 18978792; 19430480; 22623428; 23650620; 2515193; 30044821; 3366248; 8687433; 9539769; 9545226; |
| Motif | |
| Gene Encoded By | |
| Mass | 37,394 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.16; |